Green Chemistry

Metabolic Engineering Strategies for High-Level α-Pinene Production in Saccharomyces cerevisiae

Abstract α-Pinene is a biologically active monoterpene compound derived from coniferous plants, performing multiple ecological and physiological functions. Moreover, its strained bicyclic skeleton makes it an exceptional renewable feedstock for high-density renewable fuels. Howev...

Strategic uses of the past and their liabilities: why government-pushed internationalization may fail

Abstract Governments push firms to internationalize not only through diplomacy and material incentives but also by shaping the environment in which investors, host governments, and local communities form judgments about cross-border opportunities. We conceptualize this process as...

Engineering Li + Kinetic‐Buffering and Anion‐Anchoring Interphase via One‐Step Sequential In Situ Polymerization for Stable Solid Li Metal Batteries

ABSTRACT The pursuit of high‐energy solid‐state Li metal batteries is hindered by unregulated Li + deposition kinetics at the electrolyte/anode interface. Current research generally focuses on enhancing bulk ionic conductivity, often overlooking the critical need to engineer inte...

Facilitating megacity electricity decarbonization via grid-interactive demand-side resource management

City power systems face intensified mismatches between generation and dynamic demand under rising zero-carbon energy penetration levels. Although demand-side resource management offers mismatch mitigation potential by regulating load patterns, its city-level capability remains un...

AI-Guided Discoveryof Natural-Product-Inspired Scaffoldsas Dual P-gp/BCRP Inhibitors to Overcome Cancer Multidrug Resistance

Abstract ATP-binding cassette (ABC) transporters ABCB1/P-glycoprotein (P-gp) and ABCG2/breast cancer resistance protein (BCRP) drive multidrug resistance (MDR) by limiting intracellular chemotherapy accumulation, and are coexpressed in cancers with overlapping substrates. Here, w...

Guest-DrivenFlexibility in a Hydrogen-Bonded OrganicFramework for NH3 Capture

Abstract Ammonia (NH3) capture and low-energy release remain a critical challenge in adsorptive separation. Herein, we report a guest-driven flexible hydrogen-bonded organic framework (HOF), designated FDU-HOF-7, constructed from 1,3,5-benzenetricarboxylic acid. The as-synthesize...

Cavity Confinement to Create Multi‐Dimensional Functional Partition Iron Sites Synergistically Promotes Multi‐Scenario Ammonia Synthesis

ABSTRACT Electrocatalytic ammonia synthesis centered on nitrate reduction constitutes a vital component of the future green synthesis pathway from nitrogen to nitrogen oxides to ammonia. However, catalyst development often overlooks the critical coordination between the intricate...

Rationally DesignedMalonate-Derived Ligands EnableCopper-Catalyzed C–N Coupling via a Cu(I)/Cu(III) Mechanism

Abstract A class of sterically decorated, malonamide ligands has been developed to enable copper-catalyzed C–N coupling for the synthesis of pharmaceutically relevant heterocycles. This methodology facilitates the efficient coupling of aryl and heteroaryl bromides with a broad ra...

Metabolic engineering of Escherichia coli for efficient production of d-phenylglycine

d -phenylglycine (D-PHG) is a valuable building block extensively used in the synthesis of β-lactam antibiotics and other high-value pharmaceuticals. However, its conventional chemical production relies on expensive starting materials and harsh reaction conditions, while existing...

Multi-component gradients in 3D host frameworks enabled stack-type zinc plating/stripping for highly durable aqueous Zn-ion batteries

Developing dendrite-free zinc metal anodes with high durability poses a great challenge for aqueous zinc-ion batteries. Herein, we propose an in situ constructed 3D restrained host frameworks with multi-component gradients that induces a controllable and rapid stack-type zinc pla...