Great Western Hospital

Development and validation of a parsimonious AI-based mortality risk score for heart failure

Abstract Risk stratification in heart failure (HF) supports clinical decisions, yet existing tools face adoption barriers: conventional scores show modest discrimination and depend on specialised tests (i.e., echocardiography), while artificial intelligence (AI) models require ri...

Antihypertensive Treatment and Risk of Metabolic Associated Fatty Liver Disease: A Drug-Target Mendelian Randomization

BACKGROUND: Metabolic dysfunction-associated fatty liver disease, conventionally known as nonalcoholic fatty liver disease (NAFLD), affects over a quarter of the global population and lacks approved pharmacological treatments. We investigated whether elevated blood pressure (BP)...

Management of choking in Motor Neuron Disease: patient and public involvement in a co-produced mixed-methods study protocol

Abstract Background Up to 70% of people living with Motor Neuron Disease (plwMND) report distressing episodes of choking (a feeling of suffocation or airways blockage) due to involvement of bulbar muscles. There is an evidence gap on management of choking in plwMND, which is mirr...

Patient, surgeon, and institutional variation in dual-mobility component use in primary total hip arthroplasty

Aims The aim of this study was to quantify the contribution of patient-, surgeon-, and institution-level factors to variation in dual-mobility component use in primary total hip arthroplasty (DM-THA) in England. We sought to determine whether current patterns reflect appropriate...