Great Lakes Bioenergy Research Center

Metabolic modeling: the link between AI and multi-omics data to accelerate the discovery of antibiotic-resistant traits in ESKAPE pathogens

ABSTRACT The development of predictive understanding of bacterial resistance to antibiotics is one of the greatest challenges of modern medicine. Genome-scale metabolic models (GEMs) are mathematical representations of the metabolic network of a given organism assembled from geno...

Predictive models of the genetic bases underlying budding yeast fitness in multiple environments.

population. Models revealed that the predictive ability of genetic variants varied across environments, with copy number variants explaining the majority of fitness variation in most cases. Model interpretation showed that different variant types identified distinct gene sets ass...