Government of Karnataka

Experimental Investigation of Mechanical Properties of 3D-Printed Components Fabricated from Waste Plastic Extruded Filaments

Abstract The exponential global growth of post-consumer plastic waste poses severe environmental and socio-ecological challenges, necessitating innovative, decentralized recycling strategies. Simultaneously, the rapid industrial and domestic proliferation of Fused Deposition Mode...

Bistability and Bifurcation in Chaperone-Mediated Autophagy: A Mathematical Framework for Parkinson's Disease Therapeutics (PATO v1.0)

Background: Chaperone-mediated autophagy (CMA) failure is a central mechanism in Parkinson's disease (PD), driven by a positive feedback loop in which α-synuclein (αSyn) competitively inhibits LAMP2A — its own clearance receptor. Prior models have identified bistability in CMA-αS...