Government of Extremadura

Metabolic Age as a Potential Marker of Cardiometabolic Vulnerability in Institutionalised Older Adults: A Cross-Sectional Study

Background/Objectives: Chronological age is a major determinant of cardiovascular risk and metabolic syndrome, but it may not accurately reflect biological ageing or cardiometabolic vulnerability. Metabolic age has emerged as a potential indicator of metabolic health, although it...

Association of Native American, European, and African Ancestry with CYP450 Pharmacogenetics and Metabolic Phenotypes in Admixed Latin American Populations from Ecuador and Nicaragua

Background/Objectives: Interethnic variability significantly influences drug response, highlighting the importance of assessing genomic ancestry for personalized medicine. Although Latin American populations are highly admixed, they remain underrepresented in pharmacogenetic rese...

Pharmacogenetic, Clinical, Prescribing, and Demographic Predictors of Sertraline Pharmacokinetics

Background: Interindividual variability in sertraline pharmacokinetics remains substantial, but the relative contributions of pharmacogenetic (PGx), demographic, clinical, and prescribing determinants have not been comprehensively evaluated in routine clinical practice. The study...

Lifestyle and its relationship with health literacy, sense of coherence and sociodemographic factors in a Spanish primary care population: a multicenter cross-sectional study

Health behaviors are driven by a complex interplay of individual and structural factors. While health literacy and sense of coherence are widely studied as psychosocial enablers of healthy lifestyles, evidence comparing their impact against broader social determinants of health r...

BioFRAM PGx, an Implementation Proposal for Pharmacogenetics in the Spanish National Health System

Background/Objectives: Pharmacogenetics (PGx) may improve drug safety and effectiveness, but its integration into routine care remains heterogeneous across the Spanish National Health System (NHS). This article presents BioFRAM PGx, a multicentre implementation framework that def...

Thermodynamic and structural behavior of one-dimensional divalent patchy hard rods: Wertheim’s first-order thermodynamic perturbation theory vs exact results

We investigate the thermodynamic and structural properties of divalent patchy hard rods confined to a one-dimensional channel by modeling the bonding sites as attractive square-well (SW) patches located at the rod tips. The zero-range sticky limit is recovered by letting the well...