Government Medical College

Theoretical insights into functionalization-driven nitric oxide binding in calixarene scaffolds

While calixarene-based supramolecular platforms have been widely investigated for the sensing of nitric oxide (NO), the underlying host-guest interactions remain poorly understood. In the present study, dispersion-corrected density functional theory calculations were employed to...

Postmortem tumor decomposition and environmental dissemination: A narrative review of theoretical ecotoxicological risks

ABSTRACT Patients with cancer harbor a significant oncogenic load, including circulating tumor DNA, extracellular vesicles, and microRNAs, which exhibit relative stability in biofluids. This review explores the theoretical ecotoxicological risks posed by the postmortem release of...

Effect of renal denervation in chronic kidney disease: a systematic review, time-stratified meta-analysis and meta-regression of blood pressure and renal outcomes

Hypertension in chronic kidney disease (CKD) is frequently resistant to pharmacologic therapy, with sympathetic overactivity contributing to both elevated blood pressure (BP) and renal disease progression. Renal denervation (RDN) targets renal sympathetic nerves and may provide d...