Gomal University

Thiram Disrupts Hepatic and Tibial Calcium Homeostasis via ER Stress‐Mediated IP3R1 / VDAC1 Hyperactivation

ABSTRACT Thiram is an agricultural fungicide known to disrupt cellular calcium homeostasis by inducing endoplasmic reticulum (ER) stress and mitochondrial calcium overload in hepatic and growth plate (GP) tissues. Current study investigated thiram‐induced alterations at mitochond...

ELLS–NSBA three-stage framework for optimal DG/SC placement and EV integration in distribution networks

The growing penetration of distributed generation (DG), shunt capacitors (SC), and electric vehicles (EVs) in distribution networks demands optimal siting strategies that balance operational efficiency and structural resilience. Existing metaheuristic approaches treat every bus a...

Ropeginterferon alfa-2b in Polycythemia Vera: A systematic review and meta-analysis

Background: Ropeginterferon alfa-2b, a novel monopegylated interferon with improved pharmacokinetics, has emerged as a promising cytoreductive agent for managing polycythemia vera (PV). Despite increasing adoption, evidence synthesis of its efficacy and safety compared to standar...