Golestan University of Medical Sciences

A homozygous missense variant in the GUCY2D gene associated with Leber congenital amaurosis in an Iranian family: molecular docking insights and genetic analysis

Leber congenital amaurosis encompasses a genetically heterogeneous spectrum of inherited retinal disorders, typically following an autosomal recessive inheritance pattern, with onset in infancy or early childhood. Several genes have been associated with LCA, including GUCY2D , wh...

Sex-specific associations of ACE2 variants with COVID-19 hospitalization, viral load, and mortality: an Iranian hospital-based case-control study

Abstract Angiotensin-converting enzyme 2 ( ACE2 ) is the cellular receptor for SARS-CoV-2, and its genetic polymorphisms may influence COVID-19 susceptibility. This hospital-based case-control study investigated the association between three ACE2 SNPs (rs2285666, rs4646127, rs971...

Self-efficacy of oral health in pregnant women in Bojnurd, Iran: a cross-sectional study

Maintaining good oral and dental health during pregnancy is a key factor in supporting the overall health of both mother and baby. Enhancing oral and dental self-care behaviors within the community requires an understanding of the underlying factors that influence decision-making...

Trend analysis of breast cancer screening in Golestan province’s family physician program: performance evaluation for women aged 30–69

In the ranking of cancer incidence for the year, female breast cancer was the most common cancer in the north-east region of Iran. This study aimed to comprehensively evaluate the trend of breast cancer screening within Golestan province’s Family Physician Program. This repeated...

Salivary nanobiosensors for oral diseases: from biomarker discovery to clinical translation in precision dentistry

INTRODUCTION: Current diagnostic approaches to oral disease have limitations, highlighting the need for rapid, sensitive, and accessible technologies for routine clinical use. Biosensors can evaluate a wide range of biomarkers in oral conditions, including periodontal diseases, o...

Prevalence and root canal configuration of C-shaped canals in mandibular first and second molars: a retrospective cross-sectional CBCT study in a northern Iranian population

Abstract Background C-shaped canal systems show marked anatomical variation along the root and can complicate cleaning, shaping, and obturation. This study estimated their patient- and tooth-level prevalence and described their cross-sectional configurations in mandibular first a...

Treatment-associated changes in SESN2, NFATC1, and NRF2 gene expression in rheumatoid arthritis: a comparative study of newly diagnosed and DMARD-treated patients

Rheumatoid arthritis (RA) is an autoimmune disorder characterized by uncontrolled joint inflammation and progressive structural damage in the joints. Sestrin 2 ( SESN2 ) and nuclear factor erythroid-related 2 ( NRF2 ) acts as critical regulators of cellular redox homeostasis and...

Association between preoperative hypoalbuminemia and postoperative complications in spinal fusion surgery: an approach- and spinal level-stratified meta-analysis

While hypoalbuminemia is recognized as a risk factor for adverse postoperative outcomes in various surgeries, its specific impact on spinal fusion outcomes has not been systematically synthesized. This meta-analysis aimed to evaluate the association between preoperative hypoalbum...

Associations of basic and decision-making health literacy skills with psychological factors related to breast cancer screening: a bayesian network analysis

Breast cancer screening is vital for early detection, yet participation among rural women remains low. Basic and decision-making health literacy skills are associated with how individuals understand and act on screening information, and this study examined how these two skills re...

Diffusion tensor tractography of the corpus callosum in major depressive disorder: a case-control study

Major Depressive Disorder (MDD) is a common and disabling psychiatric disorder that has been associated with alterations in white-matter microstructure, including abnormalities of the corpus callosum. This study aimed to compare the brain tracts of the corpus callosum using diffu...