Gloucestershire Hospitals NHS Foundation Trust

Clinical outcomes of epiretinal membrane surgery in patients with good baseline visual acuity

PURPOSE: For patients with symptomatic epiretinal membrane (ERM), pars plana vitrectomy (PPV) with ERM peel is often performed to improve their distortion. However, there is no clear consensus on visual acuity threshold for performing surgery, nor evidence of potential likelihood...

Multiple motor proteins regulate TDP-43 anterograde axonal transport

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is also expressed in the cytoplasm, where it regulates mRNA trafficking and local translation. In nearly 97% of...

Lateral sclerosis in amyotrophic lateral sclerosis is an upper motor neuron distal axonopathy (“dying back”): a clinical-neuropathological study

Abstract The hallmark neuropathological feature of upper motor neuron (UMN) degeneration in amyotrophic lateral sclerosis (ALS) is the “sclerosis” of the lateral corticospinal tract (CST)—the major axonal pathway connecting UMNs to lower motor neurons (LMNs). However, few studies...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

From Isolation to Integration: Harnessing Restorative Clinical Supervision Within the A‐ EQUIP Model to Support Internationally Educated Radiographers in the UK

Diagnostic radiographer vacancy rates in the UK continue to rise, placing growing reliance on international recruitment to sustain the workforce. Yet, whilst internationally educated doctors and nurses benefit from established transition frameworks, no equivalent exists for inter...

Navigating dark kitchens in England: environmental health, planning, and public health perspectives

BACKGROUND: Dark kitchens, 'tech-enabled commercial kitchen(s) operating mostly for delivery, to fulfil remote on-demand consumer online orders of food for immediate consumption', are a global phenomenon. As part of a wider project exploring dark kitchens and the fast-moving onli...

Diagnosed causes of sinonasal disease in 1600 horses and associations with clinical signs, computed tomographic findings and case outcome

BACKGROUND: The diagnosis of equine sinonasal disorders has been greatly enhanced by using computed tomographic (CT) imaging. OBJECTIVES: To explore associations between specific diagnoses and clinical and CT findings and between specific diagnoses and case outcome in equine sino...

Timing of cognitive decline onset and life-course trajectories A pooled longitudinal analysis of 14,389 adults across three cohorts

Background Population ageing is driving a global surge in cognitive impairment. While late-life decline is well-characterized, the onset of measurable cognitive changes across the full adult lifespan remains uncertain. We aimed to estimate the age at which detectable decline begi...