GlaxoSmithKline (India)

Posttraumatic Stress Disorder, Health-Related Social Needs, and Cognitive Outcomes in US Veterans

Importance Posttraumatic stress disorder (PTSD) and health-related social needs (HRSNs) have been associated with cognitive decline, but their joint associations with mild cognitive impairment (MCI), Alzheimer disease (AD), and AD-related dementias (ADRD) are unclear. Objective T...

Unravelling the Itch: Cross‐Sectional Analysis of Pruritus Patterns in the PicnicHealth Primary Biliary Cholangitis Registry

BACKGROUND & AIMS: Pruritus in primary biliary cholangitis (PBC) worsens patients' health-related quality of life (HRQoL). Serum alkaline phosphatase (ALP), a biomarker of PBC activity, has an unclear relationship with pruritus severity. METHODS: This retrospective, cross-section...

Temporal effects of Palmitoylethanolamide (PEA) in modulating knee osteoarthritis symptoms: A randomized, double-blind, placebo-controlled trial

Background Osteoarthritis involves cartilage degradation, driven by elevated matrix metalloproteinases and inflammatory signalling, while available therapies offer only symptomatic relief. Palmitoylethanolamide (PEA), an endogenous fatty acid amide with anti-inflammatory and anal...

Simultaneous determination and ADME profiling of betulinic and ursolic acids from Avicennia marina in Wistar rats

Avicennia marina (grey mangrove) (AM) is a significant source of bioactive pentacyclic triterpenoids, specifically Betulinic acid (BA) and Ursolic acid (UA). Owing to their therapeutic potential, the pharmacokinetic (PK) profiles of these bioactives after administration of AM ext...

Optimising Pharmacovigilance Efficiency with MLIT (Machine Learning for Intelligent Triage): A Tool for Statistical Safety Alerts

BACKGROUND AND AIM: Pharmacovigilance is essential to ensuring patient safety by enabling timely identification of adverse reactions in increasingly complex and voluminous data. Routine quantitative signal detection methods generate statistical alerts for product-event pairs base...