GlaxoSmithKline (India)

Simultaneous determination and ADME profiling of betulinic and ursolic acids from Avicennia marina in Wistar rats

Avicennia marina (grey mangrove) (AM) is a significant source of bioactive pentacyclic triterpenoids, specifically Betulinic acid (BA) and Ursolic acid (UA). Owing to their therapeutic potential, the pharmacokinetic (PK) profiles of these bioactives after administration of AM ext...

Optimising Pharmacovigilance Efficiency with MLIT (Machine Learning for Intelligent Triage): A Tool for Statistical Safety Alerts

BACKGROUND AND AIM: Pharmacovigilance is essential to ensuring patient safety by enabling timely identification of adverse reactions in increasingly complex and voluminous data. Routine quantitative signal detection methods generate statistical alerts for product-event pairs base...