Glanrhyd Hospital

A first-in-human, phase I/IIa trial of the T cell immunotherapy personalised tumour trained lymphocytes in patients with advanced colorectal cancer: Study protocol

Background Adoptive T cell therapy is a promising alternative to conventional therapies for certain solid tumours. Personalized tumour-trained lymphocytes (pTTL) is an autologous T cell therapy derived from tumour-draining regional lymph nodes (RLNs), trained to target patient-sp...

Associations between interpreter dependency and rehabilitation outcomes and care processes following acquired brain injury: a Swedish registry-based cohort study

OBJECTIVE: To explore interpreter dependency in relation to rehabilitation outcomes and rehabilitation process measures for patients with acquired brain injury. DESIGN: Retrospective cohort study. SUBJECTS: Data from 13,900 inpatients, with acquired brain injury as main diagnosis...

Effectiveness and tolerability of low dose clindamycin for treatment of prosthetic joint infections, a retrospective cohort study

Abstract Background Clindamycin is a potential drug for treating prosthetic joint infections, but pharmacokinetic monitoring shows that coadministration with rifampicin significantly reduces clindamycin concentrations. This study aimed to describe the real-world effectiveness and...

Comparison between the blood urea nitrogen (BUN)-to-creatinine ratio and four urinary biomarkers of dehydration; a cross-sectional study in fasting patients awaiting surgery

The blood urea nitrogen (BUN)-to-plasma creatinine ratio is a conventional method for diagnosing dehydration. We examined the relationship between this method and the more recently promoted urine biomarkers of dehydration. Blood and urine sampling was performed in 921 patients wh...