Gilead Sciences (United States)

The RobinCar Family: R tools for robust covariate adjustment in randomized clinical trials

Abstract Purpose Covariate adjustment is a powerful statistical technique that can increase efficiency in clinical trials. Recent guidance from the U.S. Food and Drug Association (FDA) provided recommendations and best practices for using covariate adjustment. However, there has...

Impact on health outcomes of treating all eligible large B-cell lymphoma patients with axicabtagene ciloleucel in Portugal – A modeling approach

AIM: This study aimed to quantify the health benefits that can be achieved by treating axicabtagene-ciloleucel (axi-cel)-eligible large B-cell lymphoma patients with axi-cel instead of historical standard of care (hSoC) in Portugal. "Estimated Opportunity Lost" quantified the dif...

Inhibitors of IAP/XIAP enhance activity of sacituzumab govitecan

Abstract TROP2 antibody-drug conjugate sacituzumab govitecan (SG) is approved for treatment of advanced breast cancer. However, intrinsic and acquired resistance occur, leading to a need for novel therapies. We hypothesized that antagonists of inhibitor of apoptosis protein (IAP)...