Gifu Pharmaceutical University

Olive Oil Before Oral Glucose Delays Gastric Emptying and Lowers Glycemia Through Partially Redundant Glucagon and GLP-1 Signaling in Mice

Consumption of fat before carbohydrate (preload) attenuates postprandial glucose excursions, although the underlying mechanisms remain unclear. We investigated whether an olive oil preload (OG) reduces glycemia by engaging endocrine and neural regulation of gastric emptying. Wild...

Sustained oral drug delivery using PEGylated liposomes incorporated into polysaccharide hydrogel formulations

In this study, we combined PEGylated liposomes (PEG-Lip) with polysaccharides to sustain the oral absorption-enhancing effect of PEG-Lip. The formulated PEG-Lip had a particle size of ~100 nm and a zeta potential of about −70 mV. The polysaccharides used were carrageenan (CGN), x...

Global inequitable distribution of seminal studies of chemotherapy-induced nausea and vomiting

BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) remains one of the most quality of life limiting toxicities of cancer therapy. Decades of trials have produced robust antiemetic evidence, but their applicability to resource-limited settings where guideline-recommended...