Ghent University Hospital

Revisiting Dual-Task Paradigms for Listening Effort: Dual-Task Interference in Adults With and Without Hearing Loss

Purpose: In light of concerns about the traditional dual-task approach for behavioral listening effort, this study explored a novel dual-task interference (DTI)–based method in adults with and without hearing loss (HL). Method: Fifty-two normal-hearing individuals and 52 with HL...

Creating an Ear and Hearing Health Culture for Professional Ear Users: Current Perspectives on Challenges, Management, and Recommendations

Professional ear users (PEUs), including musicians, instrument makers, or sound engineers, depend on highly trained auditory abilities for occupational performance. Given these demands, PEUs may benefit from tailored prevention, diagnostics, and treatment. Ear and hearing disorde...

Premedication practices prior to neonatal laryngoscopy: a nationwide observational study in Belgian NICUs

Intubation or less invasive surfactant administration (LISA) in neonates both require laryngoscopy, a stressful and painful procedure. This study aimed to document premedication practices before laryngoscopy in Belgium and explore reasons for absence of premedication. Sub-analysi...

The global cost of schizophrenia: a health economic modelling study

Abstract Background Schizophrenia is a chronic psychiatric disorder that leads to substantial disability, impaired quality of life, and reduced life expectancy. In addition to its profound impact on affected individuals, the disorder places a considerable financial burden on heal...

Bacterial orbital infection leading to orbital exenteration: a case series

Orbital exenteration (OE) secondary to infection is rare. This case series reports 3 cases and aims to elucidate the possible underlying etiopathogenesis. A retrospective data analysis was performed of patients who underwent an OE and subsequently received an orbital prosthesis f...

‘It’s not fair!’ Fathers’ perceptions of injustice in the context of pediatric chronic pain: An interpretative phenomenological analysis

Recent research highlights the role of parental appraisals in pediatric pain, yet studies on injustice appraisals remain limited and largely focused on mothers. This qualitative study explores fathers' appraisals of injustice in the context of their child's chronic pain, examinin...

Functional vision head impulse testing (fvHIT) in children: Feasibility and normative values

Objectives Current pediatric vestibular care mainly focuses on motor development and postural control whereas the consequences of impaired gaze stabilization are less frequently addressed. The Functional Vision Head Impulse Test (fvHIT) offers a method to assess functional gaze s...

The influence of attention on movement-related outcomes in non-specific low back pain: a systematic review

Background Cognitive affective factors have been proposed to influence movement performance in non-specific low back pain. However, the specific influence of attention on movement performance remains an underexplored domain. Therefore, this systematic review evaluated the current...

Induction of a non-inflammatory macrophage phenotype M2 (CD206⁺MerTK⁺) by prednisolone and CTLA4-Ig (abatacept) combined treatment in cultured monocyte-derived macrophages from early diagnosed rheumatoid arthritis patients

Macrophages play crucial and bivalent roles in active and remission phases of synovitis in rheumatoid arthritis (RA). Glucocorticoids, usually prednisolone (PD), represent part of the first line of treatment in early RA. Therefore, conventional and then biological disease modifyi...

Low awareness of and adherence to preventive guidelines for hepatitis B reactivation among Belgian specialist physicians: the CHOICe study

Despite preventive screening guidelines and antiviral prophylaxis, hepatitis B virus (HBV) reactivation continues to be a problem in clinical practice, resulting in patient mortality. The CHOICe study has two main research objectives: firstly, to identify knowledge gaps relating...

Decoding the Cellular Response to Methylthioadenosine Uncovers Novel Targets for Chronic Liver Disease

Progressive familial intrahepatic cholestasis type 3 (PFIC3), caused by MDR3 deficiency (MDR2 in mice), is a lethal pediatric liver disease characterized by early-onset persistent cholestasis, progressive fibrosis, cirrhosis, and eventual liver failure. MDR3 is a phosphatidylchol...

Active, explorative, and infected: a meta‐analysis of individual variation in behaviour and parasitism

Behavioural variation among individuals strongly influences how individuals interact with their environment and, consequently, their exposure to parasites. Parasite infections, in turn, can alter host behaviour by imposing energetic costs or manipulating hosts to enhance transmis...

Drug‐Free Remission in Early Peripheral Spondyloarthritis, including Psoriatic Arthritis: 10‐year follow‐up from the CRESPA trial

OBJECTIVES: To provide a descriptive analysis of the 10-year follow-up data from the CRESPA study. Here, patients fulfilling the ASAS peripheral spondyloarthritis (pSpA) classification criteria, with symptom duration ≤12 weeks, were randomized to golimumab 50mg Q4W or placebo. Ou...

Clonal Hematopoiesis of Indeterminate Potential Proteomic Risk Score for Predicting Clinical Outcome in Patients With Heart Failure With Preserved Ejection Fraction

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is common in heart failure with preserved ejection fraction (HFpEF). However, the proteomic signatures linked to CHIP driver mutations and their prognostic implications in HFpEF remain poorly defined. We aimed to...

Ezetimibe/bempedoic acid combination in statin-induced anti-HMGCR positive immune-mediated necrotizing myopathy: a case series.

OBJECTIVES: Immune-mediated necrotizing myopathy (IMNM) is a rare but potentially life-threatening complication of statins. Subsequent management of dyslipidemia is challenging, since data on the safety and effectiveness of non-statin lipid-lowering therapies (LLT) are sparse. Ez...

A multicenter randomized, double-blinded placebo-controlled phase 2 trial to evaluate safety and efficacy of ilofotase alfa in patients at risk for kidney injury following open heart surgery

Acute impairment of kidney function after cardiac surgery is common and associated with an increased morbidity and mortality. Ilofotase alfa has demonstrated potential to attenuate renal injury through its immunomodulatory effects. We evaluated the safety and efficacy of ilofotas...

Newcomer?

Abstract Families, pupils, and students from the Dutch-Caribbean islands sometimes choose to migrate to the European part of the Dutch kingdom for work or educational purposes. Within the EDINA framework, pupils that migrate to the Netherlands who do not (fully) master the school...

MoDPA: Inferring Modification-dependent Protein Associations from Uniformly Reprocessed Mass Spectrometry

Post-translational modifications (PTMs) are key regulators of protein function and cellular processes; however, the overall principles of PTM co-regulation and crosstalk remain to be fully understood. Here, we present Modification-Dependent Protein Associations (MoDPA), a framewo...

Interest in geriatric medicine training among health and social care professionals: the roles of experience and attitudes. Findings from the online survey of the COST Action PROGRAMMING 21122

Abstract Background The growth of ageing populations is increasing the requirement for professionals trained to care for older adults. Aims To explore factors associated with interest in further training in geriatrics across health and social care professionals. Methods The COST...

Coordination and cohesion in digital ventures: a process model of alignment breakdown and reconstitution

Digital ventures that build a second product have to divide the work of two products and also continuously negotiate a shared sense of what the venture is. The mirroring hypothesis explains the first problem, that an organisation’s structure comes to correspond to the architectur...