Geriatric Research Education and Clinical Center

Preliminary accuracy, inter- and intra-rater reliability of a 4-point cervical artery dissection diagnostic decision support tool in an ambulatory setting using real and simulated cases: a quality improvement project

BACKGROUND: Cervical artery dissection (CeAD) is a rare but life-threatening condition that commonly presents with non-specific symptoms such as neck and head pain, complicating early recognition in ambulatory care settings. The CeAD diagnostic decision support tool (DDST) is a 4...

Sex-specific skeletal muscle fiber atrophy and reduced macrophage inflammation in a rodent transverse aortic constriction model

Abstract Heart failure is associated with systemic skeletal muscle remodeling, where sex-specific differences suggest differential peripheral involvement in disease progression. Skeletal muscle macrophages regulate angiogenesis and tissue remodeling and may contribute to early al...

Assessing feasibility of real‑world respiratory virus syndromic surveillance in nursing homes using point‑of‑care molecular testing

Respiratory virus surveillance varies widely between nursing homes (NHs) and is shaped by differences in staffing capacity, provider training, diagnostic resources, and facility-level protocols. CLIA-waived, point-of-care molecular testing devices were implemented as routine resp...

Modifiable Lifestyle Factors in Cardiovascular Disease Prevention: Current Evidence and Future Directions

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide despite substantial advances in pharmacologic and interventional therapies. Modifiable lifestyle behaviors are major determinants of cardiovascular risk and essential targets for primary a...

Development and pilot implementation of an educational program for concurrent use of non-steroidal anti-inflammatory drugs and glucocorticoids in older veterans with rheumatic diseases

Abstract Background Polypharmacy is common among aging Veterans with rheumatic and musculoskeletal diseases (RMDs). Veterans who concurrently use glucocorticoids (GCs) and non-steroidal anti-inflammatory drugs (NSAIDs) have higher risk of adverse events. We created the ScaLable M...

Institutional Fear of Falling—Causes, Consequences, and Cures

This Viewpoint describes the common institutional problem of patient falls, cautions that efforts to prevent them may cause harm, and suggests a focus on safe mobility and a reframing of messaging around fall risk to improve health outcomes.

Rapid Eco-AI CE–MS Enables Sub-7 Min Low-Input Proteome Profiling with Quantitative Validation

Abstract Low-input and single-cell proteomics by mass spectrometry (MS) have advanced rapidly, but balancing analytical speed and sensitivity remains challenging, especially for small, protein-scarce primary cells such as neutrophils. Here, we report Rapid Eco–AI, an optimized el...

Clinicians’ Experiences With Law Enforcement in a Pediatric Emergency Department

BACKGROUND AND OBJECTIVES: Law enforcement officers (LEOs) are frequently present in emergency departments, where their roles may include accompanying patients, investigating injuries, or responding to safety concerns. Existing research on LEO presence in health care has focused...

A Multicenter Prospective, Observational Study of Observation Versus Colectomy in Recurrent Diverticulitis

BACKGROUND: Understanding changes in quality of life that occur with colectomy is critical to decision-making in management of recurrent diverticulitis. We hypothesized that patients choosing colectomy at surgical consultation would report better disease-specific quality of life...

Use of Electroconvulsive Therapy for Catatonia in Down Syndrome Regression Disorder: A Systematic Review, Case Series, and Analysis

Abstract Purpose Down syndrome regression disorder (DSRD) is a condition occurring in young people with Down syndrome. It is associated with functional decline, new onset psychopathology, and increased support needs. DSRD is often associated with catatonia, for which electroconvu...

Deletion of P311 enhances regeneration in aged skeletal muscle

While aging results in marked decreases in the capacity of skeletal muscle to repair following injury, as well as increases in fibrosis, the pathways and factors that regulate these processes are poorly defined. P311/Nrep (P311) is a highly conserved protein known to promote fibr...

Non-enzymatic hepatic ABHD6 interacts with Akt-FoxO1 axis to regulate metabolic health

The enzymatic role of ABHD6 in insulin secretion and resistance is well documented. However, its non-enzymatic function, especially its effects on metabolic health, including selective hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD)...