Geriatric Research Education and Clinical Center

Deletion of P311 enhances regeneration in aged skeletal muscle

While aging results in marked decreases in the capacity of skeletal muscle to repair following injury, as well as increases in fibrosis, the pathways and factors that regulate these processes are poorly defined. P311/Nrep (P311) is a highly conserved protein known to promote fibr...

Non-enzymatic hepatic ABHD6 interacts with Akt-FoxO1 axis to regulate metabolic health

The enzymatic role of ABHD6 in insulin secretion and resistance is well documented. However, its non-enzymatic function, especially its effects on metabolic health, including selective hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD)...