Georgetown University Medical Center

An Analysis of the Use of Race and Ethnicity in Georgetown University Medical Center Publications

ABSTRACT Background Racial and ethnic health disparities remain a pressing issue in the United States, especially as the country grows more diverse. How race and ethnicity are discussed in medical research can influence data interpretation and the application of findings. We eval...

Conscientious objection to euthanasia: a qualitative study of palliative care physicians’ perceptions

Abstract Background Conscientious objection (CO) in healthcare is a pressing issue, particularly in euthanasia, where legal permissibility coexists with moral disagreement. CO is commonly framed as a principled refusal based on moral or religious convictions, often emphasizing te...

Personalized genomic landscape of prostate cancer in African American men reveals novel drivers and therapeutic opportunities

African American (AA) men experience disproportionately high prostate cancer incidence and mortality. Despite this disparity, current genomic repositories are predominantly derived from European populations, and studies using archived tissues are often limited by stromal contamin...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Timing Matters: Preoperative Lumbar Epidural Steroid Injection and Long-Term Outcomes Following Single-Level Posterior Lumbar Fusion

Study Design Retrospective Cohort Analysis. Objective CESIs are a mainstay of nonoperative treatment for degenerative lumbar spine disease. As increasing numbers of patients undergo sPLF after receiving CESIs, understanding their impact on surgical outcomes is essential. The obje...

Brain Penetrant Calcium Channel Blockers Were Not Associated With Reduced Alcohol Consumption: Converging Results From Two Large Independent Cohort Studies Using Electronic Health Records

ABSTRACT Purpose Alcohol use disorder (AUD) remains a major public health problem, with few effective treatments. L‐type calcium channel blockers (LTCCBs) have genetic and preclinical support as potential treatments for AUD. Methods We evaluated whether brain penetrant (BP)‐LTCCB...

Experience-driven plasticity in the secondary somatosensory cortex in people born without hands

In congenital handlessness, where individuals rely on their feet for compensatory manual functions, reorganization in the primary somatosensory cortex (SI) appears to be limited to local shifts by adjacent body parts. It remains unclear how congenital handlessness and lifelong co...

Breast cancer risk, epigenetic aging and DNA methylation clocks

Breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death among women in the United States, and is globally a common and impactful cancer. Its distinct molecular subtypes, each defined by characteristic genomic and epigenomic profiles, var...

Cervical cancer prevention and control strategy in Ethiopia: key informant clinicians’ perspective

Abstract Background: Cervical cancer is a major public health burden in Ethiopia, ranking second among women and disproportionately affecting HIV-positive individuals. In 2020, an estimated 7,445 new cases and 5,338 deaths occurred. Thus, accurate diagnosis, treatment, and pallia...

Temporally structured motor and auditory representations in covert syllable production

Inner speaking—the deliberate generation of speech through covert production mechanisms—is a common human experience. Current accounts propose that it engages sensorimotor processes similar to those underlying overt speech. Here, we asked whether motor and auditory representation...

Schizophrenia: advances in pathophysiology, management, and precision medicine

Abstract Schizophrenia is a common and severe mental condition with onset usually in late adolescence and young adulthood. Schizophrenia is caused by a combination of multiple genetic and environmental factors with significant neurodevelopmental implications. Advances in the clin...

A Novel Spray-on Dressing is Comparable to Silver Impregnated Foam Dressing in Controlling MRSA Infection and Promoting Healing

Abstract Burn injuries disrupt the skin barrier, increasing susceptibility to infection, delaying healing, and can potentially becoming life-threatening. Wound dressings mitigate this risk by protecting the wound from environmental pathogens. This study evaluated a novel antimicr...

Epigenetic Modulation by Luteolin, Quercetin and Apigenin in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Mechanisms and Therapeutic Perspectives

For many years, plants have long served as sources of potential therapeutic agents. Recently, there has been a growing interest in investigating the effects of plant bio-active compounds on epigenetic modulation of several processes—among them, modifications of DNA, histones, and...

Congenital heart disease in pregnancy and severe maternal morbidity: A distributed data network study

Abstract Introduction Pregnant people with congenital heart disease (CHD) are a growing patient population in obstetrics, yet evidence on the risk for severe maternal morbidity (SMM) has largely been limited to studies that lack specificity for CHD. We conducted this study to dem...