Gentofte Hospital

Personal Income Progression of Informal Family Caregivers of Children and Young Adults With Mental Disorders

Informal family care for a child with a mental disorder may negatively impact work capacity and decrease income. We compare prolonged sex-specific personal income progression between informal family caregivers of children/young adults with and without mental disorders. We evaluat...

Development and Validation of a Blood Test Informed Risk Prediction Model for Lung Cancer—The Copenhagen Lung Cancer Risk Model (CPH-Lung)

Purpose Lung cancer screening reduces lung cancer mortality, but identifying high-risk individuals remains difficult. We wanted to develop a blood test–based risk model (CPH-Lung) to improve risk stratification before image-based screening. Materials and Methods We included indiv...

Risk of malignant melanoma in hyperthyroid and hypothyroid female populations: Results from a large Danish cohort study

Introduction Experimental studies suggest that thyroid hormones may influence tumor development through endocrine and cellular signaling pathways. Although malignant melanoma (MM) is primarily associated with ultraviolet radiation exposure, the potential role of thyroid dysfuncti...

The future management of HS : People with HS as partners

Abstract Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease with profound impact on quality of life. Increasing recognition of the patient's role as an active partner in their own care has transformed approaches to disease management, yet a conceptual framework...

Persistent Health Disparities Among Adult Cancer Survivors

ABSTRACT Cancer survivors face elevated risks of age‐ and treatment‐related health conditions, possibly due to accelerated biological aging from cancer therapy. The role of social determinants of health (SDOH) in these aging trajectories remains understudied. We conducted a retro...

Gold Contact Sensitization, Clinical Characteristics and Associations With Autoimmune Disease: A Retrospective Cohort Study With Registry Linkage

ABSTRACT Background Gold sensitization is common, but its clinical and immunologic significance remains unclear. European data from consecutively patch tested patients are scarce. Animal models suggest that gold can induce systemic autoimmunity, but studies in humans are limited....

Occupational Exposure to Nickel and Cobalt From Hairdressing Tools: A Cross‐Sectional Study in 58 Danish Salons

ABSTRACT Background Hairdressers frequently perform wet work, which weakens the skin barrier. Repeated skin contact with metallic tools introduces an occupational allergen exposure. However, data on nickel and cobalt release from commonly handled cutting tools remain limited. Obj...

Early antimicrobial therapy and clinical outcomes of left-sided Enterococcus faecalis endocarditis: a NIDUS registry study

Abstract Purpose Antimicrobial therapy of Enterococcus faecalis endocarditis treatment is challenged by high intrinsic resistance and relapse rates. Knowledge on practice patterns is warranted. We aimed to describe early-phase monotherapy and combination therapy use in E. faecali...

Bone Anabolic Treatment in Patients With Chronic Kidney Disease: A Systematic Review

BACKGROUND: Chronic kidney disease (CKD) associated osteoporosis leads to an increased risk of bone fracture in patients with CKD. Evidence on the efficacy and safety of anti-osteoporotic medications is limited for this group. This systematic review aimed to examine the efficacy...

Sexual and relational challenges in men and women affected by prostate cancer: a Project SEXUS study

OBJECTIVES: To examine, in a nationally representative Danish study, a comprehensive range of sexual characteristics, dysfunctions and relational challenges among men with prostate cancer (PCa) aged ≥50 years and women married to such men, compared with unaffected men and women....

Depression, anxiety and PTSD symptoms in patients following emergency surgery: A systematic review and meta-analysis

Emergency surgery represents a major stressor that may increase the risk of adverse mental health outcomes. This systematic review and meta-analysis aimed to assess the incidence of clinically significant symptoms of depression, anxiety and PTSD after emergency surgery and the as...

Exploring the Feasibility and Acceptability of Compassion and Mindfulness Training for Adolescents With Type 1 Diabetes and Their Caregivers

AIM: To examine the feasibility and acceptability of mindfulness training for adolescents with Type 1 diabetes (T1D) and compassion training for caregivers. METHODS: Adolescents aged 12-17 years with T1D, and their caregivers were recruited from two diabetes centres between 2022...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Short‐Term Clinical Outcomes and Complication Timing in Patients With Postoperative Delirium After Major Emergency Abdominal Surgery: A Prospective Cohort Study

ABSTRACT Background Postoperative delirium is linked to increased morbidity, mortality, and prolonged hospitalization; however, its short‐term consequences after major emergency abdominal surgery remain insufficiently studied. Methods This prospective cohort study included 752 pa...

Advanced Pulmonary Drug Delivery Systems: A Narrative Review

Pulmonary drug delivery systems have gained increasing attention as an effective strategy for the treatment of both respiratory and systemic diseases by enabling targeted, noninvasive, and efficient drug administration through the lungs, with advantages including rapid onset of a...

Long-term Mortality and Shock-rate in Patients Surviving Out-of-Hospital Cardiac Arrest with and without early implantation of an Implantable Cardioverter Defibrillator

Introduction In patients who survive out-of-hospital cardiac arrest (OHCA), guidelines for implantation of an implantable cardioverter-defibrillator (ICD) are not unequivocal.Methods Patients resuscitated from OHCA of cardiac cause, without a reversible cause and an expected surv...

The association of home characteristics and risk of respiratory tract infections and acute otitis media in the first 18 months of life: a study of ~ 48 000 children in the Danish National Birth Cohort

Respiratory tract infections (RTIs) and acute otitis media (AOM) in the first 18 months of life have a large societal and individual impact and household conditions may be important in primary prevention thereof. To assess protective and harmful prenatal home exposures on RTIs an...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Distinct body mass index trajectories throughout childhood in girls with early puberty

Abstract Background Early pubertal development in girls has been associated with increased adiposity in childhood. However, longitudinal body mass index (BMI) trajectories preceding the diagnosis of precocious puberty (PP) or premature adrenarche (PA) are less well described. We...

Incidentally detected vertebral fractures and risk of myeloma: a prospective cohort study of 9059 CT-scanned Danish general population individuals

Vertebral fractures are frequently detected incidentally on computed tomography (CT) scans performed for other indications in individuals with no symptoms of a fracture [ 1 ]. In myeloma, >45% of patients have vertebral fractures at the time of myeloma diagnosis [ 2 ]. However, t...