Genomics Medicine (Ireland)

Single-nucleus transcriptomic analysis reveals subfield-specific cell-to-cell synaptic reorganisation of the mouse hippocampus in focal temporal lobe epilepsy

Preclinical animal models are critical tools to study the pathophysiology of epilepsy. The intra-amygdala microinjection of kainic acid in mice recapitulates key features of drug-resistant temporal lobe epilepsy, including unilateral hippocampal pathology and broad resistance to...

Comparative Transcriptomics Reveals Shared Downstream Pathways in Craniofacial Pathology

Treacher Collins syndrome and Nager syndrome are craniofacial developmental disorders caused by defects in ribosome biogenesis and RNA splicing, respectively, yet they exhibit overlapping abnormalities affecting neural crest cell-derived craniofacial structures. To investigate sh...