Geneva College

From Biomarker to Bedside: Integrated Care as the Real Innovation in Alzheimer’s Disease

For decades, clinicians treating Alzheimer’s disease could offer accurate diagnosis, symptomatic drugs, and compassionate support, but nothing that altered the course of the disease [...]

Posterosuperior and Anterior Rotator Cuff Repairs Yield Comparable 1‐Year Constant Scores in Routine Clinical Practice: A Propensity Score‐Matched Study From LaTour Group

Purpose To compare clinical outcomes and ultrasound‐assessed healing rates between posterosuperior and anterior rotator cuff repairs using propensity score matching. Methods Consecutive patients undergoing rotator cuff repair between 2015 and 2021 by a single fellowship‐trained s...

Same Target but Different Bleeding Outcomes: Insights from a Randomized Apixaban-Rivaroxaban Comparison in Patients with Acute Venous Thromboembolism

Jean-Luc Reny, Youssef Daali, Jean Terrier; Same Target but Different Bleeding Outcomes: Insights from a Randomized Apixaban-Rivaroxaban Comparison in Pati

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Phage heteroresistance in clinical Klebsiella pneumoniae isolates: impact of differentiated capsule expression on phage efficacy

Abstract Heteroresistance, commonly described in the context of antibiotics, refers to the presence of resistant subpopulations within a bacterial strain, and is recognized as a likely contributor to treatment failure. Whether population heterogeneity affects phage activity remai...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Survival benefit of deceased donor kidney transplantation versus continued dialysis: international target trial emulation

Abstract Objective To quantify the survival benefit of deceased donor kidney transplantation versus continued dialysis according to patients’ characteristics (age, diabetes, cardiovascular disease), donor quality (standard criteria donor or expanded criteria donor) and donor retr...

Comparison of birth positions for breech presentation at term: a retrospective study

Abstract Background Breech presentation accounts for 3.5 to 5.0% of all term births. The majority of term breech babies are delivered by caesarean section. When the criteria for a vaginal delivery are met and the choice is made to attempt a vaginal delivery, delivery remains a ch...

GLP-1 Receptor Agonists and Musculoskeletal Outcomes: A Systematic Literature Review and Meta-Analysis

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used for the treatment of type 2 diabetes and obesity, but their effects on musculoskeletal health remain completely misunderstood. This systematic review/meta-analysis aims to synthesise clinical data on the...

Ionophore-Based Voltammetric Ion Transfer Microscopy: Imaging Enzyme-Generated Ammonium in Flow

Abstract Spatially resolved measurements of ion concentration gradients provide valuable insight into chemical, biological, and environmental processes. Recently, Voltammetric Ion Transfer Microscopy (VITM) was introduced as a novel opto-electrochemical imaging technique capable...

Small-world organization as a representation-dependent signature of nonlinear dynamics in biological time series

Abstract Small-world topology is usually interpreted in connectivity networks, but graphs derived from individual time series have different node and edge semantics. We examined how three common time-series representations—Quantile Graphs (QG), Gramian Angular Fields (GAF), and M...

Clinical feasibility and image quality assessment of deep learning-based virtual contrast enhancement from photon-counting computed tomography

Objectives: The purpose of this study was to evaluate image quality and diagnostic performance of deep learning-based virtual contrast-enhanced (VCE) images generated from photon-counting CT (PCCT) datasets. Material and Methods: Forty consecutive patients who underwent contrast-...

Artificial intelligence and radiogenomics in the peritumoral microenvironment of gliomas: a systematic review of diagnostic performance and clinical implications

Introduction Delineating infiltrative peritumoral edema (PTE) in gliomas remains challenging due to acquisition variability and the lack of histopathological validation. We systematically assessed artificial intelligence (AI) and radiomics models for peritumoral characterization....

Little Red Dots host Black Hole Stars: A unified family of gas-reddened AGN revealed by JWST/NIRSpec spectroscopy

Abstract We construct and characterise a sample of 146 little red dots (LRDs) across 2.0 < z < 9.3, selecting all sources with v-shaped UV-optical continua from JWST NIRSpec/PRISM spectra and compact morphologies in NIRCam/F444W imaging. We show that LRD continuum spectra are wel...

Quantitative MRI Susceptibility: Mapping of Transient Ischemic Attack—A Preliminary Study

A transient ischemic attack (TIA) is a transient episode of neurological dysfunction without evidence of acute infarct demarcation on neuroimaging. The radiographic features of TIAs are uncertain, as since there is currently no perfect imaging method with which to differentiate a...

Ultra-high-field MRI reveals a venous-dominant microbleed phenotype in cerebral amyloid angiopathy: a comparative study versus 3 Tesla MRI

<h3>BACKGROUND AND PURPOSE:</h3> Cerebral microbleeds (CMB) are core MRI markers of cerebral amyloid angiopathy (CAA). Ultra-high-field 7T MRI may improve CMB detection and visualization of venous-associated CMB (vCMB), but the extent to which this reflects additional lesion dete...

Community-Associated Methicillin-Resistant Staphylococcus aureus Among Gay, Bisexual, and Other Men Who Have Sex with Men Living with HIV Who Engage in Chemsex in Barcelona, Spain: Epidemiological Patterns and Implications for Infection Control

Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are increasingly reported among gay, bisexual, and other men who have sex with men (GBMSM) engaging in chemsex, yet data remain limited. This ambispective cohort study conducted at H...

From thunder to silence: Cochlear implantation for bilateral profound sensorineural hearing loss after lightning strike

INTRODUCTION: Lightning strikes can cause diverse neuro-otologic injuries. Tympanic membrane rupture is common, whereas bilateral profound sensorineural hearing loss with vestibular dysfunction and perilymphatic fistula is rare. Cochlear implantation for lightning-induced deafnes...