Génétique Animale et Biologie Intégrative

Integrating pangenome and imputation framework reveals structural variants affecting stature and milk composition traits in French dairy cattle

BACKGROUND: Structural variants (SVs) are most effectively identified using long-read (LR) sequencing. However, such data remain scarce, and sequenced samples often lack associated phenotypic information. To overcome this limitation, we integrated pangenome-based (variation graph...

Leveraging joint-specific phenotypes for genome-wide association studies and SNP heritability estimation of equine osteochondrosis and fetlock osteochondral fragments

Equine osteochondrosis (OC) and fetlock osteochondral fragments are prevalent developmental joint disorders caused by failure of the growing skeleton, often leading to intra-articular fragments that require arthroscopic surgery and impose substantial economic and animal welfare b...

Deciphering the genomic signatures of climate vulnerability across 77 sheep breeds

Abstract Among domesticated species, sheep ( Ovis aries ) have achieved a wide geographic distribution due to their mobility, rusticity and ability to adapt to diverse environments and climatic conditions. Here, we characterise the genome-wide diversity of >1,000 sheep representi...