Genesis Medical Center

In-Context Virtual Machine: Thermodynamic Entropy Bounds and Deterministic State Orchestration in Transformer-Based Autonomous Agents

Autonomous agents built upon large language models (LLMs) frequently suffer from state drift, cumulative hallucination, and non-deterministic divergence across multi-turn reasoning and execution horizons. In this work, we formalize this failure mode from a statistical physics and...

The Liquid Canvas: A Reference Architecture for Governed Generative User Interfaces in Regulated Enterprises

Interfaces that compose themselves for each person are technically feasible, yet in regulated sectors — banking, insurance, healthcare, government — they have seen almost no production adoption. The barrier is not capability but provability: an institution cannot demonstrate, aft...

The Liquid Canvas: A Reference Architecture for Governed Generative User Interfaces in Regulated Enterprises

Interfaces that compose themselves for each person are technically feasible, yet in regulated sectors — banking, insurance, healthcare, government — they have seen almost no production adoption. The barrier is not capability but provability: an institution cannot demonstrate, aft...

Co-Folding Confidence Dispersion Is a Coarse Binder Filter, Not an Affinity Ranker: Boltz-2 sigma-iptm Evaluated Against Potency Rank, Same-Chemotype Weak Binders, and Property-Matched Decoys on Matrix Metalloproteinase-1

The dispersion of co-folding confidence across an inference ensemble is widely used to triage protein-ligand predictions, but what it measures has not been fixed against experiment. This work evaluates Boltz-2 sigma-iptm, the standard deviation of iptm over 100 diffusion samples,...

Co-Folding Confidence Dispersion Is a Coarse Binder Filter, Not an Affinity Ranker: Boltz-2 sigma-iptm Evaluated Against Potency Rank, Same-Chemotype Weak Binders, and Property-Matched Decoys on Matrix Metalloproteinase-1

The dispersion of co-folding confidence across an inference ensemble is widely used to triage protein-ligand predictions, but what it measures has not been fixed against experiment. This work evaluates Boltz-2 sigma-iptm, the standard deviation of iptm over 100 diffusion samples,...

AEON Drive: Systems Architecture for Candidate Field Coupling, Geodesic-Riding Dynamics, and Experimental Tests

The AEON Drive is an exploratory and falsifiable research framework asking whether a controlled, coherent electromagnetic field architecture could produce any reproducible interaction beyond ordinary electromagnetic momentum transfer and the extremely small spacetime curvature pr...

AEON Drive: Systems Architecture for Candidate Field Coupling, Geodesic-Riding Dynamics, and Experimental Tests

The AEON Drive is an exploratory and falsifiable research framework asking whether a controlled, coherent electromagnetic field architecture could produce any reproducible interaction beyond ordinary electromagnetic momentum transfer and the extremely small spacetime curvature pr...