General Hospital of Shenyang Military Region

Integrated multi-omics, spatial transcriptomics, and functional studies implicate MDK as a mediator of cisplatin-response phenotypes in ovarian cancer

Abstract Platinum resistance remains a central barrier to durable disease control in ovarian cancer. In this study, we integrated an ovarian cancer susceptibility GWAS, multi-omics profiling (CPTAC/TCGA), and spatial-single-cell transcriptomics to identify novel therapeutic targe...

Genetically informed prioritization of immune checkpoint–associated genes in head and neck cancer highlights HGF and AKT1

Immune checkpoint inhibitors are used to treat head and neck cancer (HNC), but clinical responses vary, and systematic genetic evaluation is needed to prioritize candidate susceptibility genes. We applied summary-data-based Mendelian randomization (SMR) and HEIDI testing to scree...

Risk prediction model and intervention strategies for intraoperative hypothermia in robotic-assisted urological surgery

To develop a risk prediction model for intraoperative hypothermia in patients undergoing robotic-assisted urological surgery and formulate hierarchical warming strategies. This single-centre retrospective study calculated the sample size using G*Power 3.1. A total of 487 patients...

Combined metabolomics and microbiota analysis reveals the therapeutic effect of indole-3-propionic acid on ovariectomy-induced osteoporosis

<title>Abstract</title> Background Osteoporosis is a process of bone tissue destruction jointly caused by chronic inflammation and oxidative stress. Indole-3-propionic acid (IPA), as a metabolic molecule of the gut microbiota, exerts anti-inflammatory and antioxidant properties....

Clinical Relevance of Bile Acid and Bile Acid-Related Therapy in Liver Cirrhosis: A Review

Cirrhosis, the end stage of various chronic liver diseases, is characterized by complex pathophysiologies and poor outcomes. Recently, dysregulation of bile acid metabolism has been increasingly recognized as a key factor in the development and progression of liver cirrhosis and...

Fingolimod overcomes cisplatin resistance in esophageal squamous cell carcinoma by targeting NUP54 to disrupt homologous recombination repair

Cisplatin resistance is a major obstacle in the treatment of esophageal squamous cell carcinoma (ESCC). To address this challenge, we screened a U.S. Food and Drug Administration (FDA)-approved drug library and identified fingolimod, an immunomodulatory agent, as a potent inhibit...