Gause Institute of New Antibiotics Russian Academy of Medical Sciences

Gramicidin S analogues as a pathway to overcome antimicrobial resistance

The growing occurrence of antimicrobial resistance represents a major challenge to global healthcare and necessitates the development of novel therapeutic agents capable of overcoming multidrug-resistant (MDR) pathogens. Gramicidin S (GS), a cyclic decapeptide antibiotic has attr...

The Current State of the Antimicrobial Resistance Problem in Russia: Risks and Responses

Abstract Antibiotics are the most important antimicrobial agents that have become the main means in humanity's fight today against infectious diseases. However, their widespread and often unjustified use has led to the development in infectious pathogens of antimicrobial resistan...

Synthesis, Cytotoxicity and Antimicrobial Action of 11 Analogs of Nifuroxazide

The global spread of multidrug-resistant bacteria, alongside the rising burden of oncological diseases, poses an increasing threat to human health and public healthcare systems worldwide. Substantial efforts are underway to discover new drugs and to reposition or repurpose existi...

Linker Engineering of Hybrid Triazole-Thiazolidine Antifungals Identifies a Promising Lead Against Drug-Resistant Candida Species

Background: The emergence of antifungal resistance and the limited number of clinically available antifungal drug classes necessitate the development of new agents with improved efficacy and safety. We investigated how linker architecture influences the antifungal activity and le...