Gates Foundation

Systemic and Mucosal Antibody Responses Against Neisseria gonorrhoeae (Ng) Outer Membrane Vesicle Antigens following Four-Component Meningococcal Serogroup B (4CMenB) Immunization in Healthy Adults: A Randomized Phase II Trial

Meningococcal serogroup B (MenB) vaccines containing outer membrane vesicles (OMVs) may provide cross-protection against Neisseria gonorrhoeae infections but vaccine-induced mucosal immune responses remain poorly characterized. This phase 2, double-blind, randomized, placebo-cont...

Portable Low-Field MRI of the Brain in Clinic and Community Settings

This cohort study evaluates portable, low-field magnetic resonance imaging (MRI) against conventional MRI in memory clinic and community cohorts.

The Governance Gap: Democratizing Drug Development Through Decision Architecture

Drug development is most exposed to governance failure where it can least afford it, in global health. The field has more predictive power than at any point in its history and roughly the same failure rate it had a decade ago. We argue that this paradox persists because the field...

Deep learning super-resolution of paediatric ultra-low-field MRI without paired high-field scans

ABSTRACT Brain magnetic resonance imaging (MRI) is essential for diagnosis and neurodevelopmental research, but the high cost and infrastructure demands of high-field MRI limit its use to high-income settings. Ultra-low-field MRI scanners offer a more affordable and energy-effici...

Modelling the impact of adopting new-generation insecticide-treated nets on malaria transmission and insecticide resistance

Abstract Background The widespread insecticide resistance increasingly threatens malaria elimination, prompting a reassessment of vector control strategies. As Tanzania transitions from standard pyrethroid-only insecticide-treated nets (ITNs) to new-generation nets, evaluating th...