Gaochun People's Hospital

HDAC11 and COMP Modulate Breast Cancer Cell Phenotypes and Osteoclastogenic Responses in a Co-culture Model

Background: Cartilage oligomeric matrix protein (COMP) interacts with stromal interaction molecule 1 (STIM1). Both COMP and histone deacetylase 11 (HDAC11) are highly expressed in breast cancer cells (BCC). Given the reported inhibitory effect of HDAC3 on COMP acetylation, HDAC11...

Predicting hemorrhagic transformation in acute ischemic stroke using a machine learning model based on clinical and HR-MRI features

Early prediction of hemorrhagic transformation (HT) in acute ischemic stroke (AIS) is critical for clinical decision-making. We aimed to develop and externally validate a highly interpretable machine learning model integrating high-resolution magnetic resonance imaging (HR-MRI) a...

Aconitine accidental poisoning: two case reports and literature review

Abstract Introduction Chinese Herbal Medicine (CHM) is widely integrated into clinical practice across Asia and other regions for disease treatment and health maintenance. Aconitine, a potent diterpenoid alkaloid derived from plants of the Aconitum genus (e.g., Aconitum carmichae...