Ganzhou People's Hospital

Beyond the Single Pathogen Paradigm in Citrus: A Pathobiome Perspective on Disease Complexes, Microbiome Dysbiosis, and Management

Citrus diseases are commonly interpreted within a single pathogen framework, yet increasing evidence shows that disease outcomes can also be shaped by mixed infections, disease-associated microbiome restructuring, host responses, and interactions among multiple biotic agents. Thi...

Neuroendoscopic‐Assisted vs. Conventional Burr‐Hole Drainage for Septated Chronic Subdural Hematoma: A Comparative Cohort Study on Efficacy and Long‐Term Functional Outcomes

ABSTRACT Objective Chronic subdural hematoma (CSDH) is prevalent in the elderly. Its septated variant poses a significant surgical challenge, as conventional burr‐hole drainage often yields suboptimal results due to incomplete evacuation. Neuroendoscopy has emerged as a potential...

Shear-Performance Analysis of Piezoelectric Anchors in Rock-Slope Monitoring

ABSTRACT Bolt-stress monitoring is essential for rock-slope stability, yet conventional methods often fail to capture internal stress evolution and shear-surface locations. This study develops a piezoelectric anchor integrated with a self-sensing piezoelectric geotechnical cable...

Jujuboside A inhibits the progression of ischemic stroke by regulating miR-583

By upregulating miR-583 to suppress inflammation and oxidative stress, JuA alleviates IS injury and represents a promising candidate neuroprotective compound.

Ursolic acid ameliorates metabolic dysfunction-associated fatty liver disease by regulating the NOX4/ROS/NLRP3 pathway

Ursolic acid (UA) is a monomeric traditional Chinese medicine with unique anti-inflammatory properties. Metabolic fatty liver (MAFL)/metabolic steatohepatitis (MASH) is an early/progressive stage of metabolic dysfunction-associated fatty liver disease (MAFLD). Whether UA affects...

Advances and Challenges in mRNA Cancer Vaccines: Individualized Design and Delivery

Since the widespread use of mRNA-based COVID-19 vaccines, significant progress has also been made in mRNA cancer vaccines. Currently, mRNA cancer vaccines represent one of the most promising treatments for advanced tumors, with several candidates in clinical trials. Compared with...

Emotional distress and pathological response to neoadjuvant immunotherapy in locally advanced gastric cancer: a multicentre retrospective cohort study

To investigate the association between emotional distress (ED) and pathological response to neoadjuvant immune checkpoint inhibitor (ICI)-based therapy in patients with locally advanced gastric cancer (GC). In this retrospective cohort study (April 2022–December 2024), 129 advanc...

A novel rare missense variant in PLCD1 is associated with recurrent spontaneous abortion and inhibits cell migration and invasion

Recurrent spontaneous abortion (RSA) is a common clinical complication during pregnancy and seriously affects the physical and mental health of women reproductive age. Its etiology and pathogenesis have not yet been fully clarified. In this study, we examined whether genetic vari...

An integrated immune-related signature reveals prognostic and immune–microbiome–genomic interactions in head and neck squamous cell carcinoma

Background Head and neck squamous cell carcinoma (HNSCC) is characterized by substantial biological diversity and heterogeneous clinical outcomes. Immune-based therapies have improved treatment options for some patients; however, reliable biomarkers capable of accurately defining...

Nonlinear association between sleep duration and depressive symptoms among US adults with chronic low back pain: Evidence from NHANES 2009–2010

Background Depressive symptoms are common among individuals with chronic low back pain (CLBP) and are associated with poorer treatment outcomes. Although sleep problems are frequently reported in this population, the dose-response association between sleep duration and depressive...

Gut Microbiota and Aldosterone Regulate Natriuretic Peptide B Expression to Drive Mitophagy and Metabolic Reprogramming in Sepsis‐Like Model of Myocardial Injury

BACKGROUND: Myocardial injury is a major contributor to mortality in sepsis, yet the mechanisms underlying gut-heart communication in sepsis-induced myocardial injury remain insufficiently defined. Natriuretic peptide B (NPPB) is a cardiac stress-responsive gene, but its involvem...

Quantitative image feature integrated digital pathology model based on deep learning and machine learning for binary histological severity stratification of ulcerative colitis

The STRIDE II consensus recognizes histopathological healing in ulcerative colitis as a key therapeutic target. This study aimed to develop and internally evaluate a quantitative image-based model for the binary classification of mild versus moderate-to-severe UC based on histopa...

Anti-cancer Properties of Wogonoside on Oral Cancer Cells: An In Vitro Approach

Background Cancer is currently regarded as one of the leading causes of high rates of death and morbidity worldwide. One of the main causes of mortality globally is still oral cancer, which is more common in underdeveloped nations where tobacco and betel nut chewing are common. T...

Nighttime Sensory–Behavioral Activation and Admission Suicidality in Young Inpatients With Major Depressive Disorder: A Retrospective Clinical‐Record Study

INTRODUCTION: Suicide risk assessment during psychiatric admission may benefit from clinically observable information beyond overall depressive symptom severity. This study examined whether clinician-documented nighttime sensory-behavioral activation was associated with admission...

miR ‐15a‐5p Regulates Ferroptosis in Glioblastoma by Targeting GLS2

ABSTRACT Aims Glioblastoma (GBM) remains the most lethal primary brain tumor, and the molecular mechanisms driving its aggressiveness are incompletely understood. Recent multi‐omics analyses have identified miR‐15a‐5p as one of the core microRNAs most closely associated with GBM....

Targeting DNA damage signaling in atherosclerosis: molecular mechanisms and therapeutic opportunities

Atherosclerosis is a lipid-driven, chronic inflammatory disease of large and medium-sized arteries that underlies major cardiovascular events and remains a leading cause of mortality and morbidity worldwide. It is characterized by the progressive formation of lipid-rich plaques w...

Integrative single-cell sequencing and machine learning analyses identify chronic inflammation and cancer-associated fibroblast subsets as drivers of adverse outcomes in ovarian cancer

Background Ovarian cancer remains the deadliest gynecological malignancy, with neoadjuvant chemotherapy (NACT) often leaving residual fibroblast-enriched disease. Methods Single-cell RNA sequencing data from 64,097 cells were analyzed using Seurat (v4.1.3) with Harmony batch corr...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Wnt5a/Ca2+ signal promotes myogenic differentiation by mediating a slow and sustained influx of Ca2+

The extracellular Ca 2+ is crucial for the regeneration of skeletal muscles, but there is still uncertainty regarding the channels through which it enters the cells. The purpose of this study is to investigate how the Wnt5a/Ca²⁺ signaling pathway promotes myogenic differentiation...