Gansu Provincial Maternal and Child Health Hospital

Dual-therapeutic niraparib-loaded chitosan nanoparticle–alginate hydrogel with adipose-derived stromal cells promotes functional and histological recovery after spinal cord injury

Background: Spinal cord injury (SCI) triggers oxidative stress, inflammation, and progressive neurodegeneration. Methods: Here, we developed a dual-therapy composite hydrogel that integrates niraparib-loaded chitosan nanoparticles (NICNPs) and adipose-derived stromal cells (ASCs)...

Histological significance of MPO, ER, and PR in endometrial polyps of premenopausal women.

BACKGROUND: Endometrial polyps (EP) can lead to irregular bleeding and infertility in women. The identification of biomarkers associated with EP holds clinical importance. METHODS: Patients who visited the hospital due to abnormal uterine bleeding, endometrial thickening, abnorma...

PediatricLiver score: a novel risk score for screening elevated liver stiffness in the pediatric population (CHESS2401)

Given the looming crisis of rapid increase in childhood obesity globally, chronic metabolic diseases have consequently emerged but without sufficient awareness among children. Reliable and accessible screening tools thus are required to screen for significant liver fibrosis in th...

Acupoint hot compress for labor-pain management: a randomized, parallel-group, controlled trial

Background Non-pharmacological pain management approaches, including acupoint hot compress, may provide valuable support for women dealing with pain during the latent stage of labor, but the evidence supporting this effect is limited. We investigated whether acupoint hot compress...

Integrated interpretability machine learning and clinlabomics analysis for the risk prediction of hepatocellular carcinoma

This study aimed to develop a hepatocellular carcinoma (HCC) risk prediction model based on clinlabomics and develop an online prediction tool to provide a novel approach for early HCC diagnosis. We retrospectively collected clinical and laboratory data from 1,017 patients (576 H...

The relationship between hemoglobin concentration in the third-trimester and gestational age, birth weight of newborns: stratified analysis based on maternal age

This study retrospectively analyzed the association between hemoglobin concentration in the third trimester of pregnancy and neonatal gestational age and birth weight, and further explored whether there were differential effects between advanced maternal age and women of reproduc...