Gansu Provincial Center for Disease Control and Prevention

Diagnostic value of neutrophil extracellular traps in community-acquired pneumonia and their potential in identifying mixed infection

Abstract Objective To explore the expression characteristics of neutrophil extracellular traps (NETs) in patients with community-acquired pneumonia (CAP), and analyze the diagnostic value of NETs as well as their correlation with different infection patterns in CAP. Methods A tot...

Immunogenicity and Safety of a Single Booster Dose of Sabin-Strain Inactivated Poliovirus Vaccine in Adolescents and Adults: A Phase IV, Open-Label Trial

Background: In China, the current national immunisation schedule extends only to 4 years of age, and no polio booster dose is recommended for adolescents or adults, with data on immunogenicity and safety in these populations lacking. This phase IV trial evaluated the immunogenici...

Climate change reshapes the potential transmission risk of human alveolar and cystic echinococcosis in western China: a projection based on MaxEnt models

BACKGROUND: Echinococcosis, a severe zoonotic parasitic disease, imposes a significant health burden in western China, primarily as alveolar (AE) and cystic (CE) forms caused by Echinococcus multilocularis (Em) and E. granulosus sensu lato (Egsl), respectively. Its transmission,...

Machine Learning–Based Cytokine Endotyping of Thyroid Eye Disease

Purpose: Thyroid eye disease (TED) exhibits profound phenotypic heterogeneity that conventional binary thyrotropin receptor antibody fails to capture. We aimed to deconstruct this heterogeneity by establishing a cytokine-derived molecular taxonomy. Methods: We profiled 102 plasma...

From raw to cooked: The impact of cooking on bioaccessibility and health risks of toxic elements in leafy vegetables

Environmental policies in China have significantly reduced toxic element fluxes in soil and air, but slower declines in atmospheric toxic element flux have increased its relative contribution to crop contamination. Leafy vegetables, with their large surface area and high capacity...

Prevalence of Keshan disease at the township level in China: a cross-sectional study

Keshan disease (KD), an endemic myocardiopathy with unclear etiology, lacks primary preventive measures. This study aimed to assess the prevalence of KD at the township level using spatial epidemiology, elucidate its distribution characteristics for further precision classificati...