Gansu Agricultural University

Epigenetic multi-omics reveals the molecular regulatory mechanism underlying liver cold resistance in Hezuo pigs

Non-shivering thermogenesis is one of the adaptive modes of heat production in animals to maintain a constant core body temperature in cold environments, in which the liver plays a crucial role. However, the underlying molecular regulatory mechanisms of this process remain unclea...

Threshold-window framework reveals management-sensitive controls of CH4 and N2O emissions in flooded rice

Rice paddies are major sources of methane (CH 4 ) and nitrous oxide (N 2 O), yet co-managing water and nitrogen (N) to limit both gases remains challenging because emissions arise from non-linear interactions among multiple drivers. We combined a two-year field experiment in subt...

Transcriptomic and metabolomic analyses reveal early coordination between redox homeostasis and phenylpropanoid metabolism associated with oat resistance to Drechslera avenae

Oat ( Avena sativa L.) is an important grain and forage crop, but oat leaf spot caused by Drechslera avenae ( D. avenae ) severely limits its production. However, the dynamic defense mechanisms underlying genotype-dependent resistance to this disease remain unclear. We characteri...

MdSPL1‐MdNF‐YB4‐MdCKX7 Module Positively Regulates Saline‐Alkali Tolerance by Mediating Cytokinin Levels in Apple

Saline-alkali stress is a major abiotic factor that compromises plant growth, crop yield, and quality. Cytokinin plays an essential role in plant responses to saline-alkali stress; however, the underlying molecular mechanisms remain unclear in apple (Malus domestica). In this stu...

Botulinum toxin type A attenuates trigeminal neuralgia-like pain by suppressing CGRP release and modulating NaV1.7-associated signaling

Trigeminal neuralgia (TN) is a disabling facial pain disorder, and current treatments remain insufficient for a substantial proportion of patients. Botulinum toxin type A (BoNT/A) has shown therapeutic benefit in TN, but its peripheral analgesic mechanisms remain incompletely und...

Bacillus velezensis and Sinorhizobium meliloti Form a Functional Complementary Alliance to Alleviate the Impact of Salt Stress on Alfalfa Growth

Salt stress is a prevalent abiotic stress worldwide, which markedly inhibits crop growth and triggers yield losses. In this study, salt-tolerant plant-growth-promoting rhizobacteria of Cerasus humilis—Bacillus pumilus and B. velezensis, which possess nitrogen-fixing, phosphate-so...

OsCYP71D10 Positively Regulates Rice Sheath Blight Resistance and is Associated with Altered Ascorbate-Related Metabolism and Redox Homeostasis

Rice sheath blight, caused by the necrotrophic fungus Rhizoctonia solani , poses a major threat to global rice production. Breeding resistant varieties represents the most sustainable management strategy. Cytochrome P450 monooxygenases play diverse roles in plant defense metaboli...

Molecular mechanism of drought resistance in oat roots revealed using integrated physiological and multi-omics analyses

Oat ( Avena sativa L.), a key forage crop, is highly susceptible to water deficit. Many studies have elucidated the mechanisms through which oat leaves respond to drought; however, little is known about these mechanisms in roots. We compared the physiological, transcriptomic, and...

Ethanolic Extract of Sophora moorcroftiana Seeds Attenuates LPS-Induced Inflammation and Oxidative Stress in RAW 264.7 Macrophages via Modulation of the p62/Keap1/Nrf2 Signaling Pathway

Despite the traditional application of Sophora moorcroftiana seeds (SMS) in Tibetan medicine for heat-clearing, damp-drying, anti-inflammatory and detoxifying properties, the anti-inflammatory mechanisms of SMS remain insufficiently understood and warrant systematic investigation...

Lineage-Associated Genomic and Phenotypic Features of Bovine Mastitis-Associated Staphylococcus aureus from Northwestern China

Staphylococcus aureus is a major contagious pathogen causing bovine mastitis, with persistence and antimicrobial resistance posing ongoing challenges in dairy herds. From July 2022 to July 2023, 942 mastitis milk samples (267 clinical, 675 subclinical) from 10 farms in northweste...

Physiological and Transcriptomic Profiling of Exogenous Jasmonic Acid-Mediated Cold Tolerance in Seedlings of Poa pratensis var. anceps cv. Qinghai

Poa pratensis var. anceps cv. Qinghai is a high-quality forage grass widely distributed across the Qinghai–Tibetan Plateau, exhibiting exceptional cold tolerance, a well-developed root system, and outstanding soil consolidation capacity, rendering it of great significance for eco...