Gannan Medical University

Shyness and Adjustment in Two Cohorts of Rural Chinese Children

ABSTRACT The present study examined relations between anxiety‐based shyness and social, school, and psychological adjustment in rural Chinese children at two different historical periods. Participants included two cohorts (2012 and 2022) in middle childhood from Southeast China (...

HTR1D triggers osteosarcoma metastasis and doxorubicin resistance via c-MYC/MAPK feedback and CCL2/5-HT-mediated M2 polarization

Osteosarcoma (OS) treatment remains hindered by frequent metastasis and resistance to doxorubicin, the standard chemotherapeutic. Despite multimodal therapy, survival for advanced disease is dismal. Identifying molecular drivers that concurrently regulate invasion and chemoresist...

Cyber-pornography use among a sample of Chinese university students: utilizing machine learning and network analysis

BACKGROUND: Due to the popularity and convenience of the internet, cyber-pornography use among youth has attracted the widespread attention of scholars. Cyber-pornography use among Chinese university students remains rarely investigated, especially based on ecological systems the...

Structural characterization of HCoV-229E and H163A main protease (Mpro) interactions with the inhibitor narlaprevir

Narlaprevir, originally developed as a clinical-stage inhibitor of the hepatitis C virus (HCV) NS3/4A protease, has recently demonstrated potent inhibitory activity against the SARS-CoV-2 main protease (M pro ), with its co-crystal structure already resolved. To elucidate the mec...

Protocol for rolling circle amplification-based nanopore sequencing of eccDNA from cell and plasma samples

Extrachromosomal circular DNAs (eccDNAs) can drive copy number variation and genomic rearrangements and act as mobile regulators of gene expression. Here, we detail a protocol for eccDNA identification from cell and plasma samples. We describe steps for sample preprocessing with...

Advances and Challenges in mRNA Cancer Vaccines: Individualized Design and Delivery

Since the widespread use of mRNA-based COVID-19 vaccines, significant progress has also been made in mRNA cancer vaccines. Currently, mRNA cancer vaccines represent one of the most promising treatments for advanced tumors, with several candidates in clinical trials. Compared with...

An integrated immune-related signature reveals prognostic and immune–microbiome–genomic interactions in head and neck squamous cell carcinoma

Background Head and neck squamous cell carcinoma (HNSCC) is characterized by substantial biological diversity and heterogeneous clinical outcomes. Immune-based therapies have improved treatment options for some patients; however, reliable biomarkers capable of accurately defining...

Oxeiptosis-Associated Molecular Subtyping and Immune Microenvironment Heterogeneity in Osteoarthritis

Background: Oxeiptosis is a ROS-induced, caspase-independent form of regulated cell death, but its role in osteoarthritis (OA) remains largely unexplored. This study aimed to identify oxeiptosis-associated molecular markers in OA synovium and establish an oxeiptosis-based molecul...

Lewis Acid Catalyzed Solvent Switching Enabled Diastereodivergent Hydroimination of Bicyclo[1.1.0]butanes

Abstract A Lewis acid catalyzed, solvent-switching diastereodivergent hydroimination of acyl bicyclo[1.1.0]butanes with diphenylmethanimine is reported. Using a rhodium Lewis acid catalyst, the reaction proceeds with excellent and predictable diastereocontrol simply by changing t...

Gut–Brain Axis-mediated Neurological Manifestations in Inflammatory Bowel Disease: Mechanisms and Disease Spectrum

Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder of the gastrointestinal tract that is frequently associated with neuropsychiatric comorbidities, such as anxiety, depression, and other neurological disorders. Accumulating evidence suggests that these neurops...

Joint association of five insulin resistance indices and frailty index with incident cardiometabolic multimorbidity in individuals with cardiovascular–kidney–metabolic syndrome stages 0–3: a prospective cohort study

Insulin resistance and frailty are closely related to cardiometabolic deterioration, yet their joint contribution to the development of cardiometabolic multimorbidity (CMM) among individuals with early-to-intermediate cardiovascular–kidney–metabolic (CKM) syndrome remains unclear...

Mechanical properties and damage evolution mechanism of rubber-gangue cemented backfill under different loading rates

Abstract This study investigates the rate-dependent mechanical behavior and damage evolution of rubber-modified cemented gangue backfill through multi-scale macroscopic and microscopic tests. A piecewise statistical damage constitutive model based on the Weibull distribution is e...

Anti-cancer Properties of Wogonoside on Oral Cancer Cells: An In Vitro Approach

Background Cancer is currently regarded as one of the leading causes of high rates of death and morbidity worldwide. One of the main causes of mortality globally is still oral cancer, which is more common in underdeveloped nations where tobacco and betel nut chewing are common. T...

Coupling metabolic reprogramming with sacrificial cell lysis: multi-omics insights into an ascorbic acid-associated Se(IV) reduction and extrusion hypothesis in Lactiplantibacillus plantarum

Mechanisms supporting microbial survival under lethal selenite [Se(IV)] concentrations during bioremediation remain elusive. This study employed integrated multi-omics to analyze Lactiplantibacillus plantarum BSe (LPB) under extreme Se(IV) stress. LPB achieved 76.32% removal at 1...

Regulation of G Protein Signaling 14 protects against cerebral ischemic reperfusion injury by inhibiting the TAK1-JNK/p38 signaling pathway.

BACKGROUND: Stroke is a crucial cause of morbidity and mortality worldwide. The regulator of G protein signaling 14 (RGS14) plays important roles in mediating multiple signaling pathways and various pathophysiological processes. However, the function of RGS14 in cerebral ischemic...

miR ‐15a‐5p Regulates Ferroptosis in Glioblastoma by Targeting GLS2

ABSTRACT Aims Glioblastoma (GBM) remains the most lethal primary brain tumor, and the molecular mechanisms driving its aggressiveness are incompletely understood. Recent multi‐omics analyses have identified miR‐15a‐5p as one of the core microRNAs most closely associated with GBM....

An efficient cross-chain interaction mechanism for large-scale multichain environments

Abstract To address the scheduling difficulties, high verification overhead, and insufficient transaction processing efficiency encountered in cross-chain interactions under high-concurrency scenarios, an efficient cross-chain interaction mechanism is proposed. First, a cross-cha...

Reproductive anxiety and fertility intentions: Gender differences in social mentality among university students

Reproductive anxiety has emerged as an important concern among university students, shaping their perceptions of fertility, family formation, and future life planning. This study explored the gendered experiences of reproductive anxiety and its influence on fertility intentions a...

Prevalence and associations of biological rhythm disorders with depression and anxiety symptoms in Chinese adolescents: A multicenter study across seven provinces

Biological rhythm disruption is increasingly implicated in adolescent emotional ill-health. We conducted a multicenter cross-sectional survey of 9,498 senior high school students (15–18 years) from seven Chinese provinces. Depressive and anxiety symptoms were assessed with the Pa...

Wnt5a/Ca2+ signal promotes myogenic differentiation by mediating a slow and sustained influx of Ca2+

The extracellular Ca 2+ is crucial for the regeneration of skeletal muscles, but there is still uncertainty regarding the channels through which it enters the cells. The purpose of this study is to investigate how the Wnt5a/Ca²⁺ signaling pathway promotes myogenic differentiation...