Ganesh Shankar Vidyarthi Memorial Medical College

A validated IL1β-induced caprine ex vivo early osteoarthritis model reveals disease-modifying efficacy of TC-S 7009 via HIF-2α inhibition

Osteoarthritis (OA) is a debilitating multifactorial joint disease lacking effective disease-modifying OA drugs (DMOADs). High failure rates for clinical trials in OA could be due to inadequate screening approaches that rely on single target strategies and late-stage disease mode...

Electronic structure and spectroscopic behavior of methisazone using DFT TDDFT and NBO analysis

A detailed quantum-chemical investigation of methisazone (MSZ) has been performed using Density Functional Theory (DFT) and Time-Dependent DFT (TD-DFT) to elucidate its structural, electronic, and spectroscopic properties. The molecular geometry was optimized at the B3LYP/6-31G l...