Fuzhou Second Hospital

Astragaloside IV improves MASLD via GCN5-LXRα/SREBP1c signaling pathway-mediated hepatic de novo lipogenesis

BACKGROUND: Astragaloside IV (AS-IV), a bioactive saponin from Astragalus membranaceus, shows promise for treating metabolic dysfunction-associated steatotic liver disease (MASLD), though its mechanisms remain unclear. PURPOSE: This study aimed to elucidate how AS-IV alleviates h...

A comparative study on the clinical efficacy and complications of proximal femoral nail antirotation and femoral neck system in the treatment of basicervical femoral neck fracture (AO/OTA 31-B3)

Basicervical femoral neck fractures (FNFs) are prone to internal fixation failure owing to their inherent biomechanical instability. This study compares the efficacy of femoral neck system (FNS) and proximal femoral nail anti-rotation (PFNA) in treating basicervical FNF. A retros...

Computed tomography-derived body composition parameters as potential predictors of severity and adverse outcomes in viral pneumonia: a retrospective study

Background Following the COVID-19 pandemic, co-infections with multiple respiratory viruses have become increasingly common, complicating the accurate prediction of disease progression and prognosis. This study assessed the use of computed tomography (CT)-derived body composition...

SOX4 facilitates osteogenic differentiation through suppressing NLRP3 transcription-mediated pyroptosis

SOX4 participates in cell differentiation, but its regulatory function and underlying mechanism in the osteogenic differentiation of MC3T3-E1 cells remain elusive. Immunofluorescence staining was used to detect SOX4 subcellular localization and co-localization with NLRP3. Alizari...

Surface morphology, printing accuracy and flexural strength of 3D-printed zirconia posts with longitudinal microgrooves

Postcore restoration is essential for compromised teeth. Zirconia is a promising material due to its esthetics, strength, and radiopacity. Additive manufacturing, particularly advanced customized jetting (ACJ) technology, enables the fabrication of complex microstructures on zirc...

Angular-optimized volumetric modulated arc therapy improves cardiac sparing and efficiency in early left-breast radiotherapy

This dosimetric study evaluated angular-optimized volumetric modulated arc therapy (AO-VMAT) with non-opposed tangential beams and dynamic jaw tracking in 15 retrospective left-sided breast cancer patients. AO-VMAT comprised two non-opposed 180° arcs: start angles were set at 300...