Fuzhou Maternity and Child Health Care Hospital

Association Between Sperm DNA Fragmentation Index and Outcomes of Fresh Embryo Transfer in IVF/ICSI Cycles: A Retrospective Cohort Study

OBJECTIVE: This study explored the impact of the sperm DNA fragmentation index (DFI) on clinical outcomes and infant safety in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) among infertile couples. METHODS: A retrospective cohort study analyzed clinical data...

Synergistic prognostic value of tumor-infiltrating lymphocytes and microvessel density in breast cancer

Breast cancer is a heterogeneous disease forming an intricate ecosystem, and its prognosis is affected by multiple factors, with the complexity of the tumor microenvironment (TME) being a pivotal determinant. Tumor-infiltrating lymphocytes (TILs) and microvessels, as key componen...

Latent profiles and predictors of fear of childbirth in late pregnancy: a parity-specific analysis

Fear of childbirth (FoC) is a common psychological concern among women in late pregnancy. Variation in reported prevalence and associated factors across studies reflects methodological heterogeneity and highlights the need for person-centred approaches to identify clinically mean...

A three-metabolite microbiota-associated signature for early risk stratification of gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes and long-term metabolic and cardiovascular risk. However, oral glucose tolerance testing at 24–28 gestational weeks limits early risk stratification. Gut microbiota-associated metabolites may reflec...

Association between perioperative D-dimer dynamics and post-treatment localized intravascular coagulation in venous malformations

OBJECTIVE: To investigate the association between the change in D-dimer levels (ΔD-dimer) and the development of localized intravascular coagulation (LIC) following surgical intervention in patients with venous malformations. METHODS: This retrospective cohort study enrolled 267...

MZB1 marks a B-cell-associated stromal-immune microenvironment in cervical squamous cell carcinoma: a multi-omics analysis

BACKGROUND: Cervical squamous cell carcinoma (CSCC) is a common gynecologic malignancy with a heterogeneous tumor immune microenvironment (TIME). The role of MZB1, a B-cell-specific molecular chaperone, in CSCC remains poorly characterized. METHODS: We performed an integrative mu...