Fundación Valle del Lili

Capillary refill time prolongation in sepsis and septic shock: supported and potential mechanisms from a pathophysiological perspective

Capillary refill time (CRT) has evolved from a bedside sign into a resuscitation target in septic shock. Although simple to measure, CRT reflects restoration of cutaneous microvascular blood flow after transient external compression and therefore integrates multiple physiological...

Fatal Neonatal mTORopathy : Expanding the Phenotypic Spectrum of RRAGC ‐Associated L ong– O lsen– D istelmaier Syndrome

ABSTRACT Dilated cardiomyopathy (DCM) is a severe cardiac condition characterized by the enlargement and impaired contraction of the heart's ventricles. Pediatric cases often present unique challenges due to their rarity and the complexity of underlying genetic causes. This study...

Availability of resources to apply the 2024 McDonald criteria: A global perspective

Background: The 3rd ECTRIMS Winter School highlighted regional and global disparities in resources needed to implement the 2024 McDonald diagnostic criteria for multiple sclerosis. Objectives: To assess the availability of paraclinical tools and regional differences in access rep...

Outcomes of CHOP versus CHOEP/EPOCH in aggressive adult T-cell leukemia/lymphoma: an international cohort analysis

Aggressive adult T-cell leukemia/lymphoma (ATL) subtypes (i.e., acute and lymphomatous) are rare diseases, and the conventional management with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) has historically yielded poor outcomes. The benefit of etoposide-conta...

Maternal and neonatal outcomes associated with expanded antibiotic therapy in preterm prelabor rupture of membranes

OBJECTIVE: To compare maternal and neonatal outcomes in women with preterm prelabor rupture of membranes (PPROM) managed expectantly with either ampicillin-erythromycin or an institutional alternative regimen combining ampicillin, ceftriaxone, and clarithromycin. METHODS: weeks (...

Subnational Heterogeneity in RSV Seasonality in Tropical Colombia, 2022–2024

Abstract Background RSV transmission in tropical settings is often assumed to occur year-round, and preventive strategies are frequently recommended accordingly. However, sub-national variation in epidemic timing remains incompletely characterized. Granular local surveillance dat...