Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana

DisMed-LLM: De-Identifying Spanish Medical Text with Large Language Models

Abstract Patient privacy and compliance with regulations such as the General Data Protection Regulation (GDPR) necessitate the robust de-identification of clinical texts. This study investigates the feasibility, computational cost, and limitations of de-identifying Spanish medica...

Exploring individual, interpersonal, community, and environmental correlates of active commuting to school among Spanish adolescents: the PACO study

Objectives To identify and analyze the individual, interpersonal, community, and environmental factors associated with active commuting to school (ACS) among Spanish adolescents, and to examine the contribution of correlates from multiple ecological domains to ACS. Methods A tota...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Eye-Tracking Assessment of Visual, Oculomotor, and Pupillary Biomarkers During Reading in Parkinson’s Disease

Parkinson’s disease (PD) is associated with visual, cognitive, and oculomotor alterations that may impair reading, highlighting the potential of eye tracking to objectively characterise these changes during a task. An observational study included 46 patients with PD, classified a...

From Trials to Treatment: Current Evidence Supporting Faricimab Use in nAMD and DME

Neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) are leading causes of visual impairment and require long-term intravitreal anti-vascular endothelial growth factor (VEGF) therapy. However, treatment burden and suboptimal real-world outcomes rem...

Mapping therapeutic exercise interventions in temporomandibular disorders: A scoping review

OBJECTIVE: Temporomandibular disorders (TMDs) are musculoskeletal conditions causing pain and functional limitations. This scoping review aimed to map therapeutic exercise interventions described in clinical studies on TMDs. METHODS: Following Joanna Briggs Institute methodology,...

Radiomics and artificial intelligence in pituitary adenomas (PitNETs): from imaging biomarkers to clinical translation

Abstract Pituitary neuroendocrine tumors (PitNETs) are common intracranial neoplasms with heterogeneous hormonal activity, invasiveness, and treatment response. Conventional MRI is central to diagnosis, but is limited in quantifying tumor heterogeneity and predicting clinically r...

Presence of Dolosigranulum pigrum in the nasopharynx and its relationship with respiratory health status in paediatric population

ABSTRACT Background Respiratory tract infections range from asymptomatic colonisation to an invasive disease. Recent studies suggest that nasopharyngeal microbiota may influence this variability. Emerging evidence points to Dolosigranulum pigrum, a nasopharyngeal commensal, as a...

Distinct Microbial and Host Proteome Signatures Relate to Proteolytic Activity in Gingival Crevicular Fluid in an Exploratory Study of Patients With Periodontitis

ABSTRACT Aim Risk assessment tools for periodontitis lack sufficient precision to predict disease progression. The aim of this exploratory study was to evaluate proteolytic activity (PA) in gingival crevicular fluid in relation to clinically assessed progression risk, microbial c...

Recombination drives genome evolution in outbreak-related Legionella pneumophila isolate

Legionella pneumophila is a strictly environmental pathogen and the etiological agent of legionellosis. It is known that non-vertical processes have a major role in the short-term evolution of pathogens, but little is known about the relevance of these and other processes in envi...