Fundación Instituto Leloir

Assessment of adult structural plasticity in Drosophila neurons

Unravelling how adult neurons reshape their architecture is key to understanding post-developmental plasticity. Drosophila clock neurons, which remodel their terminals on a daily basis, offer a unique model to examine the mechanisms underlying structural plasticity. In this study...

Covalent linkage of the papillomavirus E2 DNA-binding domain reveals a soluble amyloid-like assembly pathway

Abstract Early soluble intermediates in amyloid formation are difficult to characterize because they are transient and obscured by competing insoluble aggregation. Here, we use scE2C, an engineered covalently linked version of the HPV16 E2 DNA-binding dimer, as a tractable model...