Fundación Ciencia and Vida

Loss of cGAS alters microglial homeostasis, promotes progressive neurodegeneration, and impairs neuroimmune coordination

Abstract Background The cGAS-STING pathway has been extensively studied as a driver of neuroinflammation in the context of brain aging and neurodegeneration. However, whether cGAS plays a homeostatic role in microglial function under physiological conditions — and how its express...