Fundació Salut i Envelliment UAB

Interference by macro-B12: multicenter evaluation of polyethylene glycol precipitation and establishment of reference intervals using four different immunoassay methods

Abstract Objectives Macro-B12 interference is an underestimated cause of hypercobalaminemia that may lead to misleading clinical interpretations. The aims of this study were to evaluate the diagnostic performance of polyethylene glycol (PEG) precipitation for the detection of mac...

N-Acetylcysteine in Schizophrenia: A Convergent Redox-Based Approach to Therapeutic Potential

Schizophrenia (SCZ) remains one of the most disabling psychiatric disorders, in large part because current antipsychotics (APs) inadequately address negative symptoms and cognitive deficits. Converging evidence implicates a set of interconnected mechanisms, NMDAR hypofunction, ox...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Aging in Schizophrenia: Clinical, Biological, and Psychosocial Perspectives

Background/Objectives: Schizophrenia is a chronic psychiatric disorder traditionally associated with early adulthood; however, an increasing number of individuals are now reaching older age, highlighting the need to better understand the aging process in this population. Emerging...

Evolution of functional and mental status and quality of life in people aged 75 years and over after the COVID-19 pandemic in Spain: a prospective cohort study

The COVID-19 pandemic has had significant health and psychosocial consequences in the older adults. However, there is little community-based evidence that clearly distinguishes the effect attributable to SARS-CoV-2 infection to be differentiated from the contextual impact of the...