Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Repurposing the Insecticide Flufenerim, the Only Anti- Cryptococcus Compound Identified in the MMV Global Health Priority Box, as a Candidate for the Environmental Control of the Cryptococcosis Agents

Abstract Cryptococcus neoformans and Cryptococcus gattii are environmental fungi that cause cryptococcosis, a severe, life-threatening infection, particularly in immunocompromised individuals. Current treatments are limited by toxicity, restricted availability, and the emergence...

Mercury in Fish from Guanabara Bay, Southeast Brazil: Tissue-Specific Accumulation and Human Health Risks

Abstract Guanabara Bay is Brazil’s second-largest bay and has a long history of intense industrial and domestic pollution. Some local communities rely on fish as a primary protein source, justifying an assessment of mercury (Hg) contamination. This study determined total mercury...

Acute Ethanol Exposure Inhibits GABA Uptake in Embryonic Chicken Retina

Abstract GABA is the major inhibitory amino acid in the central nervous system (CNS), and its homeostasis is crucial for inhibitory/excitatory balance. Its reuptake is mediated by GABA transporters, including type 1 (GAT-1), a high-affinity GABA plasma membrane transporter. Ethan...

DOPAL links dopamine dysregulation to neurodegeneration: a translational systematic review and meta-analysis

3,4-Dihydroxyphenylacetaldehyde (DOPAL) is the most reactive dopamine (DA)-derived aldehyde and has been implicated in selective dopaminergic neurodegeneration in α-synucleinopathies, including Parkinson’s disease (PD) and multiple system atrophy (MSA). Here, we present the first...