Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Acute Ethanol Exposure Inhibits GABA Uptake in Embryonic Chicken Retina

Abstract GABA is the major inhibitory amino acid in the central nervous system (CNS), and its homeostasis is crucial for inhibitory/excitatory balance. Its reuptake is mediated by GABA transporters, including type 1 (GAT-1), a high-affinity GABA plasma membrane transporter. Ethan...

DOPAL links dopamine dysregulation to neurodegeneration: a translational systematic review and meta-analysis

3,4-Dihydroxyphenylacetaldehyde (DOPAL) is the most reactive dopamine (DA)-derived aldehyde and has been implicated in selective dopaminergic neurodegeneration in α-synucleinopathies, including Parkinson’s disease (PD) and multiple system atrophy (MSA). Here, we present the first...