Fuling Center Hospital of Chongqing

A retrospective cohort study of the association between triglyceride-glucose index and its derived indicators and all-cause mortality among community-dwelling adults with a history of stroke

Abstract Objective As a novel marker of insulin resistance, the triglyceride-glucose (TyG) index has been documented to correlate with mortality in coronary artery disease and heart failure. In recent years, growing attention has been paid to the relationship between the TyG inde...

Catalytic asymmetric dearomatization of (hetero)aromatic frameworks

Abstract Catalytic asymmetric dearomative cycloaddition provides a powerful route to polycyclic chiral frameworks, yet the precise control of selectivity in such cycloadditions remains a formidable challenge. Herein we report a mechanism-guided strategy that harnesses the unique...

Evaluation of bone fracture risk among men with prostate cancer treated with androgen receptor pathway inhibitor-containing therapies: a systematic review and meta-analysis

Androgen receptor pathway inhibitors (ARPIs) are widely used across multiple prostate cancer disease states, but fracture outcomes are inconsistently reported across randomized trials. We aimed to quantify the risks of all-grade and grade ≥ 3 trial-reported fracture-related adver...

Perioperative carbohydrate loading improves comfort without adverse metabolic or neonatal effects in gestational diabetes mellitus

Preoperative carbohydrate loading has been known to overcome discomfort and complications associated with cesarean section, but there is a scarcity of evidence on its safety and benefits in patients with gestational diabetes mellitus (GDM). In this study, pregnant women with norm...

Prognostic significance of DNA polymerase theta and its association with immune infiltration in hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis. DNA polymerase theta (POLQ) plays multiple roles in HCC, primarily in DNA damage repair, tumor progression, and resistance to chemoradiotherapy. However, the upstream and downstream s...