Fujita Health University Hospital

2026 revised CVIT clinical expert consensus on drug coated balloons for coronary artery disease

Abstract Drug-coated balloons (DCBs) are attracting attention as a therapeutic alternative to drug-eluting stents (DES) in percutaneous coronary interventions. DCB technology allows direct delivery of antiproliferative drugs to the vessel wall without implantation of a permanent...

Total Synthesis of Antrimycins A and D

Abstract Antrimycins A and D were isolated from Streptomyces bacteria through a screening program for natural products with anti-Mycobacterium tuberculosis activity. These compounds belong to a class of heptapeptide natural products containing four non-proteinogenic amino acids,...

Relationship between objective sleep efficiency and psychological distress in middle-aged and older Japanese: Results by work in the Shika study

Sleep quality and work, as factors related to psychological distress, have not yet been elucidated. Additionally, few studies have examined the association between sleep efficiency and psychological distress, which may affect psychological distress in middle-aged and older adults...

Influence of electroplating uniformity of enriched 68 Zn targets on radiochemical distribution in cyclotron-based 68 Ga production

Abstract Cyclotron-based production of gallium-68 ( 68 Ga) using enriched zinc-68 ( 68 Zn) targets is increasingly adopted as an alternative to generator-based systems. In this approach, electroplating of enriched 68 Zn onto target substrates is a critical upstream process; howev...

Development of a prognostic model for elderly patients with metastatic clear cell renal cell carcinoma treated with first-line immuno-oncology combination therapy.

BACKGROUND: In the era of immuno-oncology (IO) combination therapy, prognostic tools for elderly patients with metastatic clear cell renal cell carcinoma (ccRCC) are lacking. This study aimed to identify prognostic factors in elderly patients and evaluate a novel risk model using...

Differential Expression of RORγt and T-bet in ALK-Negative Anaplastic Large Cell Lymphoma

ALK-negative anaplastic large cell lymphoma (ALK-negative ALCL) frequently expresses cytotoxic molecules, which may complicate its distinction from peripheral T-cell lymphoma NOS (PTCL-NOS), particularly in cytotoxic molecule-positive cases. Among these, nodal EBV-negative cytoto...

Effects of reduced gluten intake through the inclusion of yellow pea-based products on abdominal symptoms in habitual wheat consumers: a non-randomized clinical trial

Abstract Purpose Increasing attention has been paid to individuals who report gastrointestinal symptoms following wheat consumption. In addition to wheat allergy and celiac disease, non-celiac gluten sensitivity (NCGS) has been proposed as a clinical entity. Despite persistent sy...

Aspirin Omission at the Time of Primary Percutaneous Coronary Intervention in STEMI

BackgroundThe safety of omitting up-front treatment with aspirin during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. MethodsWe conducted a multicenter, open-label, randomized trial in Japan i...

A CT-Based 3D Anatomical Mapping Study of Right Posterior Portal and Hepatic Venous Patterns: Revisiting Liver Segmentation and Its Surgical Implication

Background: Classical Couinaud’s segmentation assumes the dichotomous division of the right posterior portal vein (RPPV) into P6 and P7. However, increasing imaging evidence suggests substantial anatomical variability, limiting the intraoperative identification of segmental borde...

Associations of prior fracture site with physical function and daily living in older adults without certified long-term care needs: insights from a community-based survey

Fractures are a major health concern among older adults and may contribute to declines in physical function and independence. However, their impact may differ by anatomical site. This study examined associations between fracture site and health status, including physical function...

Clinical Impact of Gleason Pattern 5 on Doublet Versus Triplet Therapy in Metastatic Hormone‐Sensitive Prostate Cancer

BACKGROUND: Upfront treatment intensification with androgen deprivation therapy (ADT) plus an androgen receptor pathway inhibitor has become a standard approach for metastatic hormone-sensitive prostate cancer (mHSPC). However, prognosis remains poor for some patients despite sec...