Fujita Health University

Differences in Occupational and Health Accommodations for Older Workers by Workplace Size: A Text Mining Analysis of Open-Ended Responses

Abstract Objectives As labor force participation among older workers continues to increase, the nature of workplace accommodations may vary according to workplace size. In this study, we aimed to clarify the current status and characteristics of workplace accommodations that addr...

Olive Oil Before Oral Glucose Delays Gastric Emptying and Lowers Glycemia Through Partially Redundant Glucagon and GLP-1 Signaling in Mice

Consumption of fat before carbohydrate (preload) attenuates postprandial glucose excursions, although the underlying mechanisms remain unclear. We investigated whether an olive oil preload (OG) reduces glycemia by engaging endocrine and neural regulation of gastric emptying. Wild...

Beyond Symbolic Internationalization: Hidden Supervisory Burdens in International Clinical Training Programs

International clinical training in radiopharmaceutical production requires supervision within time-sensitive workflows involving radiation safety, quality control, and multidisciplinary coordination. This practice-informed perspective examines how a mismatch between institutional...

Observation of near-infrared fluorescence from within biological specimens using X-ray light-sheet microscopy for deep-tissue imaging

Abstract Light-sheet fluorescence microscopy enables rapid three-dimensional imaging of biological specimens with low phototoxicity and high signal-to-noise ratio, but its imaging depth is limited by optical scattering and absorption in tissue. X-ray light-sheet microscopy, terme...

Orthodontic and surgical treatment patterns in hemifacial microsomia: a retrospective multi-institutional study in Japan

Hemifacial microsomia is a congenital craniofacial condition characterized by variable facial asymmetry and mandibular hypoplasia. Its management often requires long-term multidisciplinary care, including orthodontic and surgical treatment. However, multi-institutional data on tr...

Comparative evaluation of spline-based and Laplace-based interpolation for joint torque field reconstruction: a simulation study

Accurate interpolation of joint torque fields across joint angle combinations is essential in experimental and clinical biomechanics. Although thin-plate spline (TPS) interpolation is widely used, its exact interpolation property renders it sensitive to outliers. The present stud...

Demographic and clinical characteristics of rapidly progressive glomerulonephritis in renal vasculitis in the Japan renal biopsy registry

This study evaluated the clinical and demographic characteristics of biopsy-proven rapidly progressive glomerulonephritis (RPGN), with histological evidence of renal vasculitis. We focused on five vasculitis-related nephritides: MPO-ANCA, PR3-ANCA, anti-GBM, IgA vasculitis (IgAV)...

Impact of baseline renal function on the clinical outcomes and safety of adjuvant nivolumab in high-risk urothelial carcinoma: a multicenter retrospective real-world study

Abstract Background Adjuvant nivolumab prolongs disease-free survival (DFS) in patients with urothelial carcinoma (UC) after radical surgery; however, evidence in those with reduced baseline renal function is limited. We investigated the impact of baseline creatinine clearance (C...

Longitudinal hemifield-specific macular ganglion cell complex thinning and its association with arterial stiffness in eyes without baseline glaucomatous abnormalities

PURPOSE: To characterize longitudinal hemifield-specific changes in macular ganglion cell complex (GCC) thickness in eyes without baseline glaucomatous abnormalities and to evaluate whether arterial stiffness, assessed by brachial-ankle pulse wave velocity (baPWV), is associated...

Implementation status, difficulties, and barriers to adopting nursing-care technologies in long-term care facilities in Japan: A prefecture-wide cross-sectional survey

Background: Japan faces a shortage of care workers due to its rapidly aging population. Although nursing care technologies can reduce caregiver burden and improve care quality, their long-term feasibility remains unclear. We investigated the implementation of these technologies a...

Gut microbial phenol impairs energy metabolism and promotes sarcopenic obesity-like phenotypes in mice

Abstract Gut microbial phenol has been recognized as a uremic toxin associated with chronic kidney disease; however, its effects under preclinical conditions remain unclear. In this study, we established a mouse model with increased endogenous phenol production using a tyrosine-r...

Effects of reduced gluten intake through the inclusion of yellow pea-based products on abdominal symptoms in habitual wheat consumers: a non-randomized clinical trial

Abstract Purpose Increasing attention has been paid to individuals who report gastrointestinal symptoms following wheat consumption. In addition to wheat allergy and celiac disease, non-celiac gluten sensitivity (NCGS) has been proposed as a clinical entity. Despite persistent sy...

Real‐World Outcomes of Olaparib in Japanese Patients With BRCA ‐Mutated Metastatic Castration‐Resistant Prostate Cancer: Exploratory Analysis of BRCA2 Loss and Microsatellite Instability Status

OBJECTIVES: Metastatic castration-resistant prostate cancer has a poor prognosis. Although olaparib has demonstrated efficacy in patients with BRCA1/2 mutations, real-world data in Japanese patients remain limited. We aimed to evaluate the efficacy and safety of olaparib in patie...

Postoperative Swallowing Function After Minimally Invasive Esophagectomy Assessed by Videofluoroscopic Swallowing Study and Cough Test

Background/Aim: Postoperative dysphagia is a common and clinically important complication after esophagectomy; however, perioperative changes in swallowing function and airway-protective reflexes have not been well characterized. Here, we aimed to evaluate perioperative changes i...

A novel SUR1‐TMD0 interaction region contributes to glucose‐dependent inhibition of pancreatic K ATP channels by bupropion

Background and Purpose Pancreatic β‐cell ATP‐sensitive potassium (K ATP ) channels play a central role in glucose homeostasis by coupling cellular metabolism to insulin secretion. Although conventional K ATP channel inhibitors are effective insulin secretagogues, their clinical u...

d‐Sorbose Promotes Regulatory T‐Cell Differentiation and Ameliorates Autoimmune and Allergic Diseases via Hexosamine Biosynthetic Pathway Inhibition

ABSTRACT Monosaccharides are fundamental biomolecules involved in various biological processes. Rare sugars, naturally scarce monosaccharide derivatives, exhibit unique physiological effects independent of standard energy metabolism. Among them, d‐sorbose, the C‐3 epimer of d‐fru...

Pneumonitis in Older Patients With Non-squamous Non-small Cell Lung Cancer Treated With Pembrolizumab and Pemetrexed

Background/Aim: Pembrolizumab combined with pemetrexed is efficacious in older patients with metastatic non-squamous non-small cell lung cancer (NSCLC) and a PD-L1 tumor proportion score (TPS) of <50%. However, treatment-related pneumonitis is concerning, and its impact on clinic...

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study ass...

Leveraging the salivary microbiome profile to stratify REM sleep behavior disorder and synucleinopathies

Abstract Few studies have explored noninvasive biomarkers of synucleinopathies, including Parkinson’s disease (PD), and rapid-eye-movement behavior disorder (RBD), a prodromal stage for these conditions. Human oral/salivary microbiomes are altered in PD, highlighting their potent...

Early administration of calcineurin inhibitors limits tolerogenic effect of PTCy in allogeneic hematopoietic transplant

We recently demonstrated early administration of calcineurin inhibitors (CNIs) after murine allogeneic hematopoietic cell transplantation (allo-HCT) inhibits terminal exhaustion of donor T cells and hampers tolerance induction. However, the role of CNIs in regulating T-cell exhau...