Fujian Provincial Hospital

Selective Cancer Cell Killing via a Fluorofoldamer‐Based Proton Channel That Triggers Ferroptosis

ABSTRACT We report a new class of aromatic foldamer‐based artificial proton channels incorporating fluorinated building blocks, which exhibit high proton transport efficiency and selectivity. The lead channel, 2 , shows outstanding proton transport activity (EC 50 = 13.1–14.7 nM)...

MRI-Based Radiomics Model for Pretreatment Prediction of Pathological Lymph Node Metastasis in Neuroendocrine Carcinoma of the Cervix: Dual-Center Development and External Validation

Objectives: To develop and externally validate MRI-based radiomics and clinicoradiomics models for predicting pathological lymph node metastasis (LNM) in neuroendocrine carcinoma of the cervix (NECC). Methods: This retrospective two-center study included 133 patients who underwen...

Antibacterial and Biocompatible Iodine-Releasing Polycationic Coatings Synthesized by Solvent-Free Initiated Chemical Vapor Deposition

Abstract Bacterial adhesion to surfaces of medical devices may cause medical device-associated infections. This challenge can be addressed by surface modification utilizing antibacterial coatings. Polycationic coatings possess excellent antibacterial activity, but their biocompat...

The VCX/VCY gene family member VCX3A encodes an RNA-binding protein that modulates the proliferation and motility of spermatogonia GC-1 cells via pre-mRNA splicing

VCX3A , a member of the VCX / VCY gene family, is predominantly expressed in spermatogonia of the male testis. Emerging evidence implicates that mutations or duplication of VCX3A may contribute to nonobstructive azoospermia. Although VCX3A has been characterized as a nuclear RNA-...

γ‐Radionuclide Technetium‐99M Activated Long‐Lasting Chemodynamic Therapy and Immunogenic Brachytherapy for Enhanced Antitumor Immunity

ABSTRACT Chemodynamic therapy (CDT) and brachytherapy face critical challenges, particularly the limited efficiency of Fenton reaction and the insufficient antitumor immunogenicity of brachytherapy. In this study, we employ the metal–organic framework nanocomposite Hf‐TCPP@Fe‐ 99...

Intraoperative tachycardia burden, diastolic hypotension, and in-hospital mortality after noncardiac surgery: a retrospective cohort study

Intraoperative hypotension is an established perioperative risk marker, but the relevance of intraoperative tachycardia remains uncertain. We examined tachycardia, diastolic blood pressure (DBP), mean arterial pressure (MAP), and temporal co-occurrence in noncardiac surgery. We c...

Quality optimization with low positive factual hallucination for the HPI in hyperthyroidism admission notes using multi agent LLM with RAG

Admission note quality affects clinical safety and research reliability, yet resident drafts often suffer from missing information, unclear logic, and other issues, requiring time-consuming manual review. Current large language models (LLMs) focus on text generation or formatting...

Dynamic cardio-renal-metabolic trajectories identify sepsis subphenotypes for individualized management: a cross-population cohort study

Sepsis heterogeneity remains a major barrier to precision medicine. Although cardio-renal-metabolic interactions critically influence outcomes, their dynamic evolution is rarely integrated into clinical phenotyping. We aimed to identify distinct sepsis subphenotypes based on dyna...

Association of serum sodium concentration and duration with 28-day mortality in critically ill patients

Abstract Dysnatremia is common in critically ill patients, but the prognostic relevance of its duration remains uncertain. This retrospective cohort study used MIMIC-IV data from 2008 to 2022. Of 94,458 ICU records screened, 9,799 adults with a first ICU stay of at least 7 days w...

Treatment disruption and psychological distress among hemophilia patients during the COVID-19 pandemic: the role of healthcare accessibility

The strict zero-COVID policies in China, lasting from early 2020 to late 2022, posed unique challenges to chronic disease management. While the pandemic’s mental health impact is well-documented, evidence regarding patients with hemophilia remains limited. This study aimed to ass...

Systemic artery-to-pulmonary artery fistulas and recurrence of noncancer-related hemoptysis after bronchial artery embolization: a retrospective study

To investigate the clinical and angiographic characteristics of systemic artery-to-pulmonary artery fistulas (SA-PAFs) in patients with noncancer-related hemoptysis undergoing bronchial artery embolization (BAE), and to assess their associations with procedural outcomes and recur...

Prognostic value of preprocedural right ventricular free-wall longitudinal strain for one-year mortality after transcatheter aortic valve implantation

TAVI has improved outcomes in severe AS, yet residual mortality risk remains. Current risk models primarily rely on left ventricular parameters, with limited incorporation of right ventricular function. To evaluate the prognostic value of preprocedural RV-FWLS for 1-year mortalit...

Association and predictive value of the C-reactive protein-triglyceride-glucose index in chronic kidney disease

Abstract Recent evidence has suggested a positive association between the C-reactive protein-triglyceride-glucose index (CTI) and chronic kidney disease (CKD), but its generalizability and prognostic utility remain to be fully established. In this study, we examined the CTI and C...

Repurposing diuretics for bipolar disorder: a Mendelian randomization study

Despite increasing therapeutic options to treat bipolar disorder (BD), many patients fail to reach treatment targets. The study sought to explore the potential of diuretics in preventing and treating BD through Mendelian randomization (MR). We utilized a two-sample MR design to a...

Gut Microbiota and Aldosterone Regulate Natriuretic Peptide B Expression to Drive Mitophagy and Metabolic Reprogramming in Sepsis‐Like Model of Myocardial Injury

BACKGROUND: Myocardial injury is a major contributor to mortality in sepsis, yet the mechanisms underlying gut-heart communication in sepsis-induced myocardial injury remain insufficiently defined. Natriuretic peptide B (NPPB) is a cardiac stress-responsive gene, but its involvem...

Predicting radiation esophagitis after lung cancer radiotherapy using dose-volume, radiomic and dosiomic features: an external validation study

Acute radiation esophagitis can interrupt thoracic radiotherapy, but it remains unclear whether image- and dose-derived features improve prediction beyond dose-volume histogram (DVH) metrics and retain their performance across institutions. We externally validated seven models ba...

FGF23 promotes atrial fibrillation susceptibility through ETV1‐dependent sodium channel regulation and calcium handling abnormalities

Abstract Fibroblast growth factor 23 (FGF23) is closely associated with atrial fibrillation (AF), yet whether it modulates sodium and calcium currents in atrial myocytes remains unclear. ETV1, a key transcription factor regulating atrial electrical conduction, may also be involve...

MTAP deficiency in lung cancer cells enhances proliferation and migration and increases vulnerability to bone metastasis

Lung cancer continues to be the leading cause of cancer-related death worldwide. The advent of molecular targeted therapies has significantly changed the treatment landscape. Therefore, identifying new molecular targets is essential for the development of more effective treatment...

Ultrathin 2D Multivariate Hydrogen‐Bonded Organic Framework Nanosheets for Fluorescent DNA Sensing

The multivariate strategy is generally incompatible with densely packed structures, as this approach typically requires porous frameworks to manage the steric demands of incorporated functional groups. Without sufficient free volume, the frameworks are prone to structural transfo...

Uncertainty-inspired open-set model for identifying infantile fundus abnormalities

Accurate and safe identification of infantile fundus abnormalities is critical for large-scale screening, yet remains challenging because of heterogeneous disease presentations and overconfident predictions by conventional artificial intelligence (AI) models. In this study, we ai...