Fudan University Shanghai Cancer Center

Extracellular vesicle-derived circ6853 drives vascular remodeling and serves as a potential biomarker and therapeutic target for gastric cancer

Gastric cancer (GC), a leading global malignancy, urgently requires the discovery of novel diagnostic and therapeutic targets. The roles of extracellular vesicle (EV)- derived circular RNAs (circRNAs) as diagnostic biomarkers and functional regulators, particularly in vascular re...

Nebulized lidocaine for preventing postoperative pulmonary complications in major abdominal surgery

Despite the lung-protective ventilation strategy, high incidence of postoperative pulmonary complications (PPCs) after major non-cardiac surgery remains a major concern in the perioperative care due to high morbidity and mortality. The study aimed to evaluate the efficacy and saf...

Evaluation of 68Ga Labeling Strategies and Thermostability of HER2-Targeted Nanobody NB46

Abstract The HER2-targeted nanobody NB46 was evaluated for labeling strategy flexibility and thermostability. Random and site-specific 68Ga labeling strategies were compared. Both conjugates exhibited high HER2 affinity, comparable to unmodified NB46. Cellular uptake, pharmacokin...

Real-world clinical outcomes of trastuzumab deruxtecan in patients with HER2-low metastatic breast cancer

Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) approved for HER2-low metastatic breast cancer (mBC), showing improved survival outcomes in clinical trials. However, real-world evidence on its effectiveness among Chinese patients remains limited. Patients with...

Characterization of SPP1 + macrophages and their correlation with resistance to neoadjuvant chemotherapy in colorectal cancer liver metastasis

Neoadjuvant chemotherapy (NAC) for colorectal cancer liver metastasis (CRLM) remains a major clinical challenge, with outcomes varying widely among patients, yet the mechanisms that drive therapeutic resistance remain incompletely understood. In this study, we integrated single‑c...

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

ABSTRACT Acquired resistance to temozolomide (TMZ) remains a major therapeutic challenge in glioblastoma (GBM), with metabolic reprogramming emerging as a critical driver of treatment failure. Procollagen lysyl hydroxylase 1 (PLOD1) is identified as a key regulator of adaptive me...

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

ABSTRACT Limited aqueous dispersibility and potential off‐target toxicity hinder the development and clinical translation of proteolysis‐targeting chimeras (PROTACs). Herein, a bioactive self‐delivering “Split Nano‐Assembly of Photosensitizers and Targeting Chimeras” (SNAP‐TAC) t...

Large language model–assisted preoperative communication reduces patient anxiety and physician workload in prostate cancer: a prospective randomized phase II trial

Abstract This prospective, randomized, single-blinded, phase II trial evaluated whether large language model (LLM)-assisted preoperative communication, compared with standard communication, reduces patient anxiety and improves illness perception and satisfaction while decreasing...

Distinct Molecular Landscape and Clinical Subtype of HPV-Positive Esophageal Squamous Cell Carcinoma

Background: This study aimed to investigate the prevalence of human papillomavirus (HPV) infection in Chinese patients with esophageal squamous cell carcinoma (ESCC) and its association with driver gene mutations (EGFR, KRAS, PIK3CA, PTEN), clinicopathological features, and progn...

Eggerthella lenta disrupts the gut vascular barrier to drive colorectal cancer liver metastasis

Distant metastasis is the leading cause of death in colorectal cancer (CRC), and the gut vascular barrier (GVB) is the first obstacle to hematogenous spread. To investigate whether GVB function is directly influenced by metastasis-associated bacteria, we analyzed two cohorts comp...

HSP90 shields ROC1/RBX1 from proteasomal degradation by CHIP E3 ubiquitin ligase to promote lung adenocarcinoma

The Regulator of Cullins 1 (ROC1) or RING box protein-1 (RBX1) is an essential component of the largest multiunit Cullin-RING ubiquitin ligase (CRL). Previous studies demonstrated that ROC1 is frequently overexpressed in multiple malignancies, which predicts advanced cancer stage...

Association between serum cotinine levels and prostate-related clinical endpoints

Abstract Purpose This study examined the association between serum cotinine, an objective biomarker of tobacco exposure, and prostate-related clinical endpoints in men participating in the National Health and Nutrition Examination Survey. Methods Cross-sectional data from five NH...

Summary of Research: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination with Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer

This is a summary of a research article reporting the findings of the HER2CLIMB-05 trial (NCT05132582), a randomized, double-blind, placebo-controlled, international, phase III trial. The HER2CLIMB-05 trial was conducted to compare the efficacy and safety of adding tucatinib vers...

The combination of farnesol and berberine effectively inhibits Candida albicans growth and biofilm formation

Abstract The formation of Candida albicans biofilms is a key factor contributing to clinical antifungal treatment failure and multidrug resistance (MDR). Overcoming biofilm formation is an urgent priority in antifungal therapy. Here, we report a synergistic strategy utilizing far...

ESAM reduces sensitivity to anti-HER2 therapy in HER2-positive breast cancer by activating the mTOR pathway

Abstract Despite improved survival rates with dual trastuzumab and pertuzumab therapy, patients with HER2-positive breast cancer frequently experience disease progression due to intrinsic or acquired resistance. Elucidating the underlying mechanisms of resistance and identifying...

Exploratory integration of spatial transcriptomics and MRI phenotypes to characterize metastasis-associated microenvironmental features in ipsilateral breast tumor recurrence

Ipsilateral breast tumor recurrence (IBTR) presents a critical clinical challenge, as it is strongly associated with a high risk of subsequent distant metastasis, the primary cause of mortality. Although the spatial organization of the tumor microenvironment (TME) may contribute...

A Manganese-Chlorella Hydrogel for an Integrated “Remove–Remodel–Repair” Strategy in Pancreatic Cancer Therapy

Abstract Pancreatic cancer faces the challenges of tumor progression and postoperative pancreatic fistula during the perioperative period, which severely affect patient prognosis. In this study, an injectable self-healing multifunctional hydrogel (CMCGel) was developed based on d...

A multi-stage prospective study evaluates serum metabolomic signatures for the differential diagnosis and prognostic stratification of PDAC

Background Pancreatic ductal adenocarcinoma (PDAC) lacks biomarkers for accurate diagnosis and prognostic stratification. The standard, CA19-9, has suboptimal specificity in differentiating PDAC from mimics like chronic pancreatitis (CP). We investigated serum metabolomic signatu...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...