Friedrich Miescher Institute

Large transgene arrays cause aberrant transcription and synthetic molting defects

Abstract Multicopy transgene arrays remain widely used in Caenorhabditis elegans research. It is usually assumed that they behave neutrally, not impacting the phenotype under investigation. Here, we reveal that a previously reported heterochronic extra-molt phenotype associated w...

Teaching Signal Synchronization in Deep Neural Networks with Prospective Neurons

Abstract Working memory requires the brain to maintain information from the recent past to guide ongoing behavior. Neurons can contribute to this capacity by slowly integrating their inputs over time, creating persistent activity that outlasts the original stimulus. However, when...