Fraunhofer Institute for Toxicology and Experimental Medicine

Molecular characterization of colorectal cancer liver metastases with pure desmoplastic versus non-pure desmoplastic histopathological growth patterns using a targeted gene expression panel

The histological growth pattern (HGP) at the interface of colorectal adenocarcinoma liver metastases (CRCLM) and liver parenchyma provides important prognostic information. This study aimed to identify transcriptomic signatures underlying the predominant HGPs in CRCLM. We retrosp...

Qualification of a Swellable Hydrogel–Silicone Bimorph for Implantable Actuation

To improve the structural adaptability and biological suitability of cochlear implant electrode carriers, this study systematically develops and evaluates novel 3D-printed, swellable hydrogel–silicone composites. A vinylphosphonic acid–acrylamide hydrogel powder (VPA-AAm) was pre...

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E6...

Harnessing macrophage signaling pathways and scalable engineering for next-generation immunotherapies

Macrophages have emerged as promising candidates for cell-based immunotherapies due to their intrinsic plasticity, tissue-infiltrating capabilities, and central roles in orchestrating immune responses. Their phenotypic and functional diversity within tissues and the tumor microen...