Frankfurt Institute for Advanced Studies

Mesoscale structures in signed networks

Mesoscale structures in signed networks have been studied under the limiting assumption of the validity of social balance theory, which predicts positive connections within groups and negative connections between groups. Here, we propose and apply a methodology that overcomes thi...

DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells

Abstract Histone lysine demethylase 4 (KDM4) enzymes are frequently overexpressed in cancer and are considered to be promising therapeutic targets. QC6352, which is widely used as a best-in-class KDM4 chemical probe, shows potent antitumor activity across cancer models. Using com...

Spin effects in superfluidity, neutron matter, and neutron stars

We review selected aspects of the interior physics of compact stars, focusing on the microscopic and macroscopic manifestations of spin, magnetic fields, and nucleonic superfluidity and superconductivity. Spin statistics of fermions allow quantum degeneracy pressure to determine...

Multiscale patterns of migration flows in Austria: regionalization, administrative barriers, and urban-rural divides

Abstract Migration is central to various societal problems related to socioeconomic development. While much of the existing research has focused on international migration, migration patterns within a single country remain relatively unexplored. In this work, we study internal mi...

Fast-Forward: Automatic Assignment and Assessment of Bonded Parameters for the Martini Force Field

Abstract Coarse-grained molecular dynamics simulations of bio- and macromolecular systems offer a method of accessing otherwise unobtainable time and length scales, compared to atomistic simulation techniques. However, a limiting step is often the generation and validation of the...