Frankfurt Cancer Institute

DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells

Abstract Histone lysine demethylase 4 (KDM4) enzymes are frequently overexpressed in cancer and are considered to be promising therapeutic targets. QC6352, which is widely used as a best-in-class KDM4 chemical probe, shows potent antitumor activity across cancer models. Using com...

Sleep duration links to biological aging clocks: when sleep gets tough, aging gets going

In a recent large-scale study of biological ageing clocks published in Nature , the MULTI Consortium now shows sleep, often treated as a lifestyle habit, is a measurable sign of temporal biology. Their work suggests that deviations from optimal sleep duration are associated with...

Oncofetal cell states: cell plasticity drives invasion in premetastatic colorectal tumors

In a recent publication in Nature , Buissant des Amorie et al. provide evidence that an oncofetal cell state which is associated with advanced disease, chemoresistance and metastatic competence emerges already in early-stage T1 colorectal cancer (CRC). Intriguingly, oncofetal cel...

Mechanistic insights into phage dynamics to overcome intracellular bacterial reservoirs in urinary tract infections

Abstract Recurrent urinary tract infections frequently arise from uropathogenic bacteria invading bladder epithelial cells, where they establish persistent intracellular reservoirs. Phages represent a promising therapeutic alternative to antibiotics owing to their host specificit...

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective

Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatm...