Framingham Heart Study

Epigenome-Wide Association Study of Abdominal Aortic Aneurysm Identifies Central Role for Inflammatory Pathways

BACKGROUND: Epigenetic mechanisms underlying susceptibility to abdominal aortic aneurysm (AAA) remain poorly understood. Identifying causal DNA methylation markers for AAA can elucidate the regulatory processes that drive aneurysm formation and accelerate translational applicatio...

Musculoskeletal pain and atrial fibrillation: the Framingham Heart Study

Given the morbidity and mortality of atrial fibrillation (AF), identifying factors associated with its onset is a priority. Chronic pain affects one-third of Americans and is linked to cardiovascular disease outcomes, including stroke and mortality. Since there are common pathoph...

Associations of Brain Structure and Neuropsychological Function With Artificial Intelligence Estimates of Biological Vascular Age

BACKGROUND: Accelerated vascular aging, assessed as artificial intelligence–based vascular age (AIVA), is associated with small vessel disease that may impact brain structure and neuropsychological function. METHODS: In a cross-section of Framingham Heart Study participants, AIVA...

Factors associated with longitudinal survey adherence and smartwatch usage among older adults in the electronic Framingham Heart Study

Sustaining long-term adherence to digital health protocols remains a major challenge, and factors influencing sustained use of digital devices among older adults are poorly understood. We identified sociodemographic, health-related, and technological factors associated with longi...

Consensus-Based Definitions for Vocal Biomarkers: The International VOCAL Initiative.

Introduction: Voice-based health technologies are growing rapidly, but they lack standardized terminology, which hinders interdisciplinary collaboration, research quality, and clinical translation. The objective of this work was to develop universally accepted definitions in the...

Transcriptome signatures associated with cognitively unimpaired individuals with pathologically confirmed Alzheimer disease

There is growing interest in cognitive resilience to Alzheimer’s disease (AD), given limited success of therapies targeting hallmark proteins. Gene expression in the prefrontal cortex region obtained from brain donors in three cohorts was compared among pathological controls and...