Fox Chase Cancer Center

Cannabis use and perceptions among rural and urban cancer patients and survivors from a Pennsylvania cancer center

PURPOSE: Cannabis use has become more common among cancer patients for symptom management. Given the underrepresentation of rural patients in prior research, our study explored cannabis use and perceptions among cancer patients, with a focus on comparing rural and urban/suburban...

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling

Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid...

Modeling Therapy Sequence for Advanced Cancer: A Microsimulation Approach Leveraging Electronic Health Record Data

Purpose: Many patients with advanced cancers undergo multiple lines of treatment. Optimal therapy sequence (ie, what therapies are given and in what order) is often unknown. We developed methods for estimating quality-adjusted outcomes and cost-effectiveness of therapy sequences,...

Prevalence of meeting aerobic physical activity and resistance training guidelines in advanced prostate cancer: a descriptive study of racial and regional disparities in the IRONMAN registry

Abstract Purpose To estimate guideline-based aerobic physical activity and resistance training participation in an international population of people with newly diagnosed metastatic hormone-sensitive or castration-resistant prostate cancer, and to assess racial and regional diffe...

Cirrhosis severity modulates proteomic and immune landscapes in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) most often arises in cirrhotic livers, yet the biological impact of cirrhosis severity on the tumor proteome remains poorly understood. Here, we performed a comprehensive quantitative proteomic analysis of 141 HCC tumors stratified by the d...

Molecular basis of nick ligation in the nucleosome by DNA Ligase IIIα

Eukaryotic genomic DNA is packaged into chromatin through a fundamental repeating unit known as the nucleosome core particle. Within this chromatin context, genomic DNA is constantly exposed to endogenous and exogenous stress that result in the formation of DNA damage, which must...

Patient-focused intervention versus enhanced care-as-usual in facilitating gynecologic cancer patients’ clinical communication about sexual health: protocol for a randomized controlled trial

Sexual problems are common, distressing, and persistent for patients with gynecologic cancer (GC). Yet patients with GC often hesitate to raise sexual concerns with their clinicians due to discomfort and inadequate preparation for the discussion. The objective was to evaluate the...

Starve-Feed Cycles Direct Quiescence to Proliferation Transitions in Drosophila Follicle Stem Cells via Transcriptional Regulation

Stem cell quiescence is a reversible state in which cells temporarily exit the cell cycle but remain poised to re-enter, on cue. Robust protection of the balance between stem cell quiescence and proliferation (Q->P) is critical for long-term tissue health. Proliferation without p...

Adjuvant CDK4/6 inhibitors in early‐stage breast cancer: Clinical evidence and considerations for risk stratification and treatment selection

Hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer is the most common biologic subtype and carries a persistent risk of recurrence, particularly in patients with high-risk, early-stage disease. Cyclin-dependent kinase 4 and 6 inhibitors, in...

Cross-cultural adaptation of cancer health literacy instruments in Arabic: the CHLT-30-Arabic and CHLT-6-Arabic

Background Health literacy plays a crucial role in physical and mental health outcomes. Patients with chronic diseases, cancer patients in particular, shoulder a disproportionate burden due to limited health literacy. Limited cancer health literacy (LCHL) is a risk factor for dis...

Recent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD)

Abstract Von Hippel-Lindau disease (VHLD) is a rare autosomal dominant disease, occuring in ~ 1 in 35,000 individuals. Overall, individuals with inherited mutations in the VHL tumor suppressor gene are predisposed to a variety of cancer, including high frequencies of clear cell r...

Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity

Abstract Mutations are fundamental to oncogenesis, yet they cannot fully explain cancer progression, as oncogenic mutations frequently accumulate in healthy tissues without immediate malignancy. In the liver, β-catenin mutations are highly prevalent in hepatocellular carcinoma bu...

Establishment and genomic validation of novel patient-derived xenograft models for drug discovery in gastrointestinal stromal tumor

Abstract Most gastrointestinal stromal tumor (GIST) patients develop clinical resistance to approved tyrosine kinase inhibitors (TKI). The development of effective treatment strategies for refractory GIST requires identification of novel targets for investigational agents and wel...

A Randomized Hybrid Type I Effectiveness-Implementation Study of an eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Cancer (eREACH2): study protocol

Abstract Background Germline cancer genetic testing has become a standard evidence-based practice, with established risk reduction and cancer screening guidelines for genetic carriers. There are also targeted treatments for some genetic carriers with cancers such as breast and ov...