Institution
Fox Chase Cancer Center
Recent research
- Health & MedicineOpen access
Background Health literacy plays a crucial role in physical and mental health outcomes. Patients with chronic diseases, cancer patients in particular, shoulder a disproportionate burden due to limited health literacy. Limited cancer health literacy (LCHL) is a risk factor for dis...
- BiologyOpen access
Recent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD)
Abstract Von Hippel-Lindau disease (VHLD) is a rare autosomal dominant disease, occuring in ~ 1 in 35,000 individuals. Overall, individuals with inherited mutations in the VHL tumor suppressor gene are predisposed to a variety of cancer, including high frequencies of clear cell r...
- BiologyOpen access
Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity
Abstract Mutations are fundamental to oncogenesis, yet they cannot fully explain cancer progression, as oncogenic mutations frequently accumulate in healthy tissues without immediate malignancy. In the liver, β-catenin mutations are highly prevalent in hepatocellular carcinoma bu...
- Health & MedicineOpen access
Abstract Most gastrointestinal stromal tumor (GIST) patients develop clinical resistance to approved tyrosine kinase inhibitors (TKI). The development of effective treatment strategies for refractory GIST requires identification of novel targets for investigational agents and wel...
- BiologyOpen access
Abstract Background Germline cancer genetic testing has become a standard evidence-based practice, with established risk reduction and cancer screening guidelines for genetic carriers. There are also targeted treatments for some genetic carriers with cancers such as breast and ov...